Fe3O4/TiO2 and Fe3O4/CuO nanohybrid materials have attracted widespread attention due to their scientific and technological importance as photocatalyst. Complicated process is usually used to synthesize these nanohybrid. In this study, we demonstrated a simple low-temperature sol-gel method to prepare Fe3O4/TiO2/CuO nanohybrid as photocatalyst. Hexavalent chromium was used as a model pollutant to evaluate their photocatalytic activity. The results of the photoreduction of hexavalent chromium in aqueous solution indicated that with the incorporation of CuO content in Fe3O4/TiO2 nanohybrid increasing the photocatalytic performance in ultraviolet and visible region. Moreover, it is found that hydroxyl radical has an important role in photocatalytic efficiency.