Preparation, characterization and in vitro release study of microcapsule simvastatin using biodegradable polymeric blend of poly(L-lactic acid and poly(ɛ-caprolactone) with double emulsifier

Findi Citra Kusumasari, Lukmanul Hakim Samada, Emil Budianto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Simvastatin is a cholesterol-lowering agent that inhibits the microsomal activity of 3-hydroxy-3-methylglutaril-CoA-reductase (HMG-CoA reductase), enzyme that contributes in biosynthesis cholesterol. Simvastatin has short half-life elimination about 2 hours and low solubility, this condition makes its bioavailability to be quite small. Simvastatin has adverse effect such as myopathy and rhabdomyolysis because of higher dose consumption of simvastatin. Controlled drug delivery system is needed to reduce the adverse effect. One of method that is used in drug delivery system is encapsulation using biodegradable polymer such as poly(L-lactic acid) and poly(ɛ-caprolactone). PLLA and PCL was blended with fix composition PLLA: PCL 60: 40 (%w/w) by solvent evaporation technique using Tween 80 and Span 80 as emulsifier. Based on the optimization, the best encapsulation efficiency microcapsules were obtained at concentration of Tween 80 0.025% (v/v), Span 80 1% (v/v) with stirring speed at 900 rpm for 1 hour. The encapsulation efficiency was 83.67%. The best microcapsules were dissolved in dissolution media to get drug release profile. The percentage of drug release at pH 1.2 was 0.86% for 3 hours and in the phosphate buffer solution pH 7.4 for 12.22% for 52 hours.

Original languageEnglish
Title of host publicationMetal Materials Processes and Manufacturing
EditorsDong-Won Jung
PublisherTrans Tech Publications Ltd
Pages178-183
Number of pages6
ISBN (Print)9783035716320
DOIs
Publication statusPublished - 1 Jan 2020
Event2nd International Conference on Metal Material Processes and Manufacturing, ICMMPM 2019 - Jeju, Korea, Republic of
Duration: 30 Jul 201931 Jul 2019

Publication series

NameMaterials Science Forum
Volume977 MSF
ISSN (Print)0255-5476

Conference

Conference2nd International Conference on Metal Material Processes and Manufacturing, ICMMPM 2019
Country/TerritoryKorea, Republic of
CityJeju
Period30/07/1931/07/19

Keywords

  • Dissolution
  • Encapsulation efficiency
  • Microcapsule
  • O/w solvent evaporation
  • Poly(L-lactic acid)
  • Poly(ɛ-caprolactone)
  • Simvastatin
  • Span 80
  • Tween 80

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