Preparation, characterization, and encapsulation efficiency test of simvastatin microencapsulation using polyblend of poly(Lactic acid) and poly(ɛ-caprolactone)

Rahmi Hayatunnufus, Galuh Putri Erika Wati, Emil Budianto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Simvastatin is one of the most extensively used drugs to reduce blood cholesterol levels, which practically insoluble in water and not well absorbed from the gastrointestinal tract. In this study, simvastatin was encapsulated using polyblend of PLA and PCL in the composition of 60:40 by solvent evaporation technique (oil-in-water). The optimization of agitation rate, solvent removal time, emulsion time, and emulsifier concentration have been conducted to obtain the maximum efficiency to encapsulate simvastatin in the matrix polymer. The result showed that the optimum conditions to increase the encapsulation efficiency of simvastatin in the microcapsule using polyblend of PLA and PCL were obtained in the agitation rate, solvent removal time, emulsion time, and Tween 80 concentration as an emulsifier at 700 rpm, 1 hour, 1 hour, and 0.5% (v/v), respectively.

Original languageEnglish
Title of host publicationNano Engineering and Materials Technologies III
EditorsKazuo Umemura
PublisherTrans Tech Publications Ltd
Pages21-25
Number of pages5
ISBN (Print)9783035714302
DOIs
Publication statusPublished - 1 Jan 2019
Event7th International Conference on Nanostructures, Nanomaterials and Nanoengineering, ICNNN 2018 and International Conference on Materials Technology and Applications, ICMTA 2018 - Sapporo, Japan
Duration: 26 Oct 201829 Oct 2018

Publication series

NameMaterials Science Forum
Volume947 MSF
ISSN (Print)0255-5476

Conference

Conference7th International Conference on Nanostructures, Nanomaterials and Nanoengineering, ICNNN 2018 and International Conference on Materials Technology and Applications, ICMTA 2018
CountryJapan
CitySapporo
Period26/10/1829/10/18

Keywords

  • Microcapsules
  • O/W Solvent Evaporation
  • Poly(lactic acid)
  • Poly(ɛ-caprolactone)
  • Polyblend
  • Simvastatin
  • Tween 80

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