TY - GEN
T1 - Preparation, characterization, and encapsulation efficiency test of simvastatin microencapsulation using polyblend of poly(Lactic acid) and poly(ɛ-caprolactone)
AU - Hayatunnufus, Rahmi
AU - Wati, Galuh Putri Erika
AU - Budianto, Emil
N1 - Publisher Copyright:
© 2019 Trans Tech Publications, Switzerland.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Simvastatin is one of the most extensively used drugs to reduce blood cholesterol levels, which practically insoluble in water and not well absorbed from the gastrointestinal tract. In this study, simvastatin was encapsulated using polyblend of PLA and PCL in the composition of 60:40 by solvent evaporation technique (oil-in-water). The optimization of agitation rate, solvent removal time, emulsion time, and emulsifier concentration have been conducted to obtain the maximum efficiency to encapsulate simvastatin in the matrix polymer. The result showed that the optimum conditions to increase the encapsulation efficiency of simvastatin in the microcapsule using polyblend of PLA and PCL were obtained in the agitation rate, solvent removal time, emulsion time, and Tween 80 concentration as an emulsifier at 700 rpm, 1 hour, 1 hour, and 0.5% (v/v), respectively.
AB - Simvastatin is one of the most extensively used drugs to reduce blood cholesterol levels, which practically insoluble in water and not well absorbed from the gastrointestinal tract. In this study, simvastatin was encapsulated using polyblend of PLA and PCL in the composition of 60:40 by solvent evaporation technique (oil-in-water). The optimization of agitation rate, solvent removal time, emulsion time, and emulsifier concentration have been conducted to obtain the maximum efficiency to encapsulate simvastatin in the matrix polymer. The result showed that the optimum conditions to increase the encapsulation efficiency of simvastatin in the microcapsule using polyblend of PLA and PCL were obtained in the agitation rate, solvent removal time, emulsion time, and Tween 80 concentration as an emulsifier at 700 rpm, 1 hour, 1 hour, and 0.5% (v/v), respectively.
KW - Microcapsules
KW - O/W Solvent Evaporation
KW - Poly(lactic acid)
KW - Poly(ɛ-caprolactone)
KW - Polyblend
KW - Simvastatin
KW - Tween 80
UR - http://www.scopus.com/inward/record.url?scp=85066235017&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/MSF.947.21
DO - 10.4028/www.scientific.net/MSF.947.21
M3 - Conference contribution
AN - SCOPUS:85066235017
SN - 9783035714302
T3 - Materials Science Forum
SP - 21
EP - 25
BT - Nano Engineering and Materials Technologies III
A2 - Umemura, Kazuo
PB - Trans Tech Publications Ltd
T2 - 7th International Conference on Nanostructures, Nanomaterials and Nanoengineering, ICNNN 2018 and International Conference on Materials Technology and Applications, ICMTA 2018
Y2 - 26 October 2018 through 29 October 2018
ER -