TY - JOUR
T1 - Preparation and characterization of polyvinyl alcohol-chitosan-tripolyphosphate hydrogel for extended release of anti-tuberculosis drugs
AU - Mulia, K.
AU - Chadarwati, S. A.
AU - Rahyussalim, A. J.
AU - Krisanti, E. A.
N1 - Funding Information:
The authors are grateful for the financial support received from the Ministry of Research, Technology and Higher Education of the Republic of Indonesia through the PDUPT Research Grant contract 410/UN2.R3.1/ HKP05.00/2018.
Publisher Copyright:
© 2019 IOP Publishing Ltd.
PY - 2019/12/5
Y1 - 2019/12/5
N2 - Polyvinyl alcohol (PVA)-chitosan-tripolyphosphate hydrogels were prepared using a solvent casting-evaporation method to obtain anti-TB drugs extended release formulations. X-ray diffraction and scanning electron microscope results indicated that chitosan reduced the crystallinity of PVA hydrogels and the polymers formed homogeneous mixtures. The added chitosan reduced the encapsulation efficiency, and, the rate of drug release. The profile release of the four drugs indicated that the formulation of 80% PVA-20% chitosan hydrogel matrix had the highest drug release rate in a short period of time in phosphate buffer solution of pH 7.4. The maximum drug loading efficiency was obtained in a matrix formulation contain only PVA, while the addition of sodium tripolyphosphate increased the drug loading efficiency and also reduced the amount of drug released. The hydrogel matrix formulation of PVA-chitosan-tripolyphosphate showed its potential to be used as an extended delivery system for anti-TB drugs.
AB - Polyvinyl alcohol (PVA)-chitosan-tripolyphosphate hydrogels were prepared using a solvent casting-evaporation method to obtain anti-TB drugs extended release formulations. X-ray diffraction and scanning electron microscope results indicated that chitosan reduced the crystallinity of PVA hydrogels and the polymers formed homogeneous mixtures. The added chitosan reduced the encapsulation efficiency, and, the rate of drug release. The profile release of the four drugs indicated that the formulation of 80% PVA-20% chitosan hydrogel matrix had the highest drug release rate in a short period of time in phosphate buffer solution of pH 7.4. The maximum drug loading efficiency was obtained in a matrix formulation contain only PVA, while the addition of sodium tripolyphosphate increased the drug loading efficiency and also reduced the amount of drug released. The hydrogel matrix formulation of PVA-chitosan-tripolyphosphate showed its potential to be used as an extended delivery system for anti-TB drugs.
UR - http://www.scopus.com/inward/record.url?scp=85078305599&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/703/1/012010
DO - 10.1088/1757-899X/703/1/012010
M3 - Conference article
AN - SCOPUS:85078305599
SN - 1757-8981
VL - 703
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - 1
M1 - 012010
T2 - 2nd International Conference on Informatics, Technology and Engineering 2019, InCITE 2019
Y2 - 22 August 2019 through 23 August 2019
ER -
