Preparation and characterization of microspheres based on blend of poly(lactic acid) and poly(ε-caprolactone) with poly(vinyl alcohol) as emulsifier

Tetty Kemala, Emil Budianto, Bambang Soegiyono

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)

Abstract

In this paper, microspheres were prepared by oil-in-water (o/w) emulsion solvent evaporation method. Biodegradable polymer such as blend of poly (lactic acid) (PLA) and poly(ε-caprolactone) (PCL) with certain compositions and characteristics was used to prepare the microspheres with poly(vinyl alcohol) (PVA) as an emulsifier. This study observed the microspheres particle's size distribution at various concentrations of PVA (1%, 1.5%, 2%, and 2.5% PVA). The PVA volume variations effects during the process (50, 100, 150, 200, and 250. mL) were also observed. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The microspheres physical size and appearance were observed by optical microscope (MO). The overall results of this study showed that the formula which used 50-150. mL of 2.5% polyvinyl alcohol produced the microspheres with the most uniform size distribution.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalArabian Journal of Chemistry
Volume5
Issue number1
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • Microspheres
  • Oil-in-water emulsion
  • Poly(ε-caprolactone)
  • Poly(lactic acid)

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