This study presents the preparation of nanostructured lipid carrier (NLC) loaded extract of Zingiber officinale. Roxc. Var rubrum or Red Ginger (RG-NLC) using High-Pressure Homogenizer method with different the number of cycles. The RG-NLC formulation was characterized concerning particle size, polydispersity index (PDI), zeta-potential, particle shape and entrapment efficiency. The morphological study was performed by using Zetasizer Nano S and the entrapment efficiency analysis of NLC was performed using HPLC by detecting -, (8)-, (10)-gingerol and (6)-shogaol as active biomarkers. The average particle size for RG-NLCs ranged from size 131 to 154 nm and a polydispersity index of 0.104 to 0.172. The zeta potential of the RG-NLC differed −33.00 ± 1.57 to -46.53 ± 0.38 mV and transmission electron microscopy showed that the particles were spherical in shape. Entrapment efficiency was higher more than 98% for (6)-gingerol, but other active biomarkers were less than 96 %.
|Number of pages||5|
|Journal||Journal of Pharmaceutical Sciences and Research|
|Publication status||Published - Oct 2017|
- High-pressure homogenizer
- Nanostructured lipid carrier
- Red ginger