Preparation and characteristics of nanostructured lipid carrier (NLC) loaded red ginger extract using high pressure homogenizer method

Siti Sadiah, Effionora Anwar, Mahdi Djufri, Umi Cahyaningsih

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

This study presents the preparation of nanostructured lipid carrier (NLC) loaded extract of Zingiber officinale. Roxc. Var rubrum or Red Ginger (RG-NLC) using High-Pressure Homogenizer method with different the number of cycles. The RG-NLC formulation was characterized concerning particle size, polydispersity index (PDI), zeta-potential, particle shape and entrapment efficiency. The morphological study was performed by using Zetasizer Nano S and the entrapment efficiency analysis of NLC was performed using HPLC by detecting [6]-, (8)-, (10)-gingerol and (6)-shogaol as active biomarkers. The average particle size for RG-NLCs ranged from size 131 to 154 nm and a polydispersity index of 0.104 to 0.172. The zeta potential of the RG-NLC differed −33.00 ± 1.57 to -46.53 ± 0.38 mV and transmission electron microscopy showed that the particles were spherical in shape. Entrapment efficiency was higher more than 98% for (6)-gingerol, but other active biomarkers were less than 96 %.

Original languageEnglish
Pages (from-to)1889-1893
Number of pages5
JournalJournal of Pharmaceutical Sciences and Research
Volume9
Issue number10
Publication statusPublished - Oct 2017

Keywords

  • High-pressure homogenizer
  • Nanostructured lipid carrier
  • Red ginger

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