Preparasi dan Karakterisasi Nanosuspensi dengan Polivinilpirolidon (PVP) Sebagai Pembawa Nanopartikel Senyawa Asam Mefenamat

Several methods and technologies to increasing the solubility and dissolution rate of adrug substance has been successfully developed, such as forming of a complexingcompound, salt preparation, adjusting the pH, making of solid dispersions, etc. Oneof the technologies that are being developed is nanoparticle technology. Micronizationof drug that is processed to produce particles with nano-size. This research aims tocreate and characterize nanosuspension with Polyvinylpyrrolidone (PVP) as thevehicle of mefenamic acid nanoparticles using vibrating mill and ultrasound equipment.Nanosuspension obtained was characterized by optical microscope and PSA toperform optimization nanosuspension formed. The result of characterization showedthat the nanosuspension have an average diameter is 623.9 nm. Then, nanosuspensionof mefenamic acid was freeze drying. Nanosuspension and bulk of mefenamic acidwere characterization by XRD and put in a hard capsule shell for dissolution test.Profile of dissolution test with tris buffer media indicates that nanosuspension ofmefenamic acid has a pattern of drug release is slower and constant compared with themefenamic acid. bulk.