TY - JOUR
T1 - Predictors of advanced fibrosis in elderly patients with biopsy-confirmed nonalcoholic fatty liver disease
T2 - The GOASIA study
AU - Pitisuttithum, Panyavee
AU - Chan, Wah Kheong
AU - Piyachaturawat, Panida
AU - Imajo, Kento
AU - Nakajima, Atsushi
AU - Seki, Yosuke
AU - Kasama, Kazunori
AU - Kakizaki, Satoru
AU - Fan, Jian Gao
AU - Song, Myeong Jun
AU - Yoon, Seung Kew
AU - Dan, Yock Young
AU - Lesmana, Laurentius
AU - Ho, Khek Yu
AU - Goh, Khean Lee
AU - Wong, Vincent Wai Sun
AU - Treeprasertsuk, Sombat
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/4/6
Y1 - 2020/4/6
N2 - Background: The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population. Methods: We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis. Results: Of the 1008 patients, 175 were elderly [age 64 (62-67) years], who were matched with 525 non-elderly patients [46 (36-54) years]. Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p < 0.001). By multivariable analysis, factors associated with advanced fibrosis in elderly patients included female sex [odds ratio (OR) 3.21; 95% confidence interval (CI) 1.37-7.54] and hypertension (OR 3.68; 95%CI 1.11-12.23). The area under receiver-operating characteristics curve (95% CI) of aspartate aminotransferase-to-platelet ratio index, NAFLD fibrosis score and Fibrosis-4 index for predicting advanced fibrosis in elderly patients were 0.62 (0.52-0.72), 0.65 (0.55-0.75) and 0.64 (0.54-0.74) respectively. Conclusions: Elderly patients with NAFLD had a higher prevalence of advanced fibrosis than non-elderly patients. Female and hypertension were predicting factors for advanced fibrosis in the elderly. Non-invasive fibrosis scores had a lower specificity in elderly.
AB - Background: The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. non-elderly patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD); 2) identify predictors of advanced fibrosis in elderly patients with NAFLD; and 3) assess the performance of non-invasive fibrosis scores in the prediction of advance fibrosis in the elderly population. Methods: We abstracted the data of 1008 patients with NAFLD from nine centers across eight countries. Characteristics of elderly and non-elderly patients with NAFLD were compared using 1:3 sex-matched analysis. Results: Of the 1008 patients, 175 were elderly [age 64 (62-67) years], who were matched with 525 non-elderly patients [46 (36-54) years]. Elderly patients were more likely to have advanced fibrosis (35.4% vs. 13.3%; p < 0.001). By multivariable analysis, factors associated with advanced fibrosis in elderly patients included female sex [odds ratio (OR) 3.21; 95% confidence interval (CI) 1.37-7.54] and hypertension (OR 3.68; 95%CI 1.11-12.23). The area under receiver-operating characteristics curve (95% CI) of aspartate aminotransferase-to-platelet ratio index, NAFLD fibrosis score and Fibrosis-4 index for predicting advanced fibrosis in elderly patients were 0.62 (0.52-0.72), 0.65 (0.55-0.75) and 0.64 (0.54-0.74) respectively. Conclusions: Elderly patients with NAFLD had a higher prevalence of advanced fibrosis than non-elderly patients. Female and hypertension were predicting factors for advanced fibrosis in the elderly. Non-invasive fibrosis scores had a lower specificity in elderly.
KW - Advanced fibrosis
KW - Elderly patients
KW - Nonalcoholic fatty liver disease (NAFLD)
UR - http://www.scopus.com/inward/record.url?scp=85083071939&partnerID=8YFLogxK
U2 - 10.1186/s12876-020-01240-z
DO - 10.1186/s12876-020-01240-z
M3 - Article
C2 - 32252638
AN - SCOPUS:85083071939
SN - 1471-230X
VL - 20
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 88
ER -
