Baby bottle tooth decay syndrome (BBTDS) can compromise the development of the child. The prevention of BBTDS requires an analysis of microbiological aspects. Factors known to play a role in BBTDS include glucosyltransferase (Gtf) polymorphisms of S.mutans and salivary level of mucin MG2. Factors involved in BBTDS caused by S. mutans serotypes c and f are unknown. The present study aimed to detect the risk of caries associated with gtfB and gtfC polymorphisms in S. mutans serotypes c and f, in addition to mucin MG2 levels, in children aged 3-5 years with BBTDS. Methods: This was a cross-sectional study of prospective data on 41 children in a caries-free group and 41 in a caries group. Salivary and plaque samples were collected from for clinical examinations and laboratory analyses. Polymorphisms band detected by PCR analyses and Mucin levels measured in Elisa reader. Results: For the gtfB polymorphism, bands at 700, 800, 1500,and 2000 were an indicator of caries, whereas bands at 500 and 2000 were an indicator of caries in the presence of the gtfC polymorphism. An increase of 0.02 inmucin levels increased the tooth deft score by ±1. Conclusion: S.mutans serotype c and a combination of gtfB and gtfC polymorphisms were associated with the greatest increase in mucin levels. The mucin MG2 level exhibited a significant association with the incidence of caries, S.mutans serotype, and gtf polymorphism.
|Number of pages||10|
|Journal||Journal of International Dental and Medical Research|
|Publication status||Published - 1 Jan 2017|
- Baby bottle tooth decay syndrome
- Mucin MG2
- Polymorphisms gtfB and gtfC
- S. mutans