TY - JOUR
T1 - Prediction baby bottle tooth decay based on streptococcus mutans glucosyltransferase polymorphisms and salivary mucin MG2
AU - Fauziah, Eva
AU - Sutadi, Heriandi
AU - Winiati, Endang
N1 - Publisher Copyright:
© 2017, University of Dicle.
PY - 2017
Y1 - 2017
N2 - Baby bottle tooth decay syndrome (BBTDS) can compromise the development of the child. The prevention of BBTDS requires an analysis of microbiological aspects. Factors known to play a role in BBTDS include glucosyltransferase (Gtf) polymorphisms of S.mutans and salivary level of mucin MG2. Factors involved in BBTDS caused by S. mutans serotypes c and f are unknown. The present study aimed to detect the risk of caries associated with gtfB and gtfC polymorphisms in S. mutans serotypes c and f, in addition to mucin MG2 levels, in children aged 3-5 years with BBTDS. Methods: This was a cross-sectional study of prospective data on 41 children in a caries-free group and 41 in a caries group. Salivary and plaque samples were collected from for clinical examinations and laboratory analyses. Polymorphisms band detected by PCR analyses and Mucin levels measured in Elisa reader. Results: For the gtfB polymorphism, bands at 700, 800, 1500,and 2000 were an indicator of caries, whereas bands at 500 and 2000 were an indicator of caries in the presence of the gtfC polymorphism. An increase of 0.02 inmucin levels increased the tooth deft score by ±1. Conclusion: S.mutans serotype c and a combination of gtfB and gtfC polymorphisms were associated with the greatest increase in mucin levels. The mucin MG2 level exhibited a significant association with the incidence of caries, S.mutans serotype, and gtf polymorphism.
AB - Baby bottle tooth decay syndrome (BBTDS) can compromise the development of the child. The prevention of BBTDS requires an analysis of microbiological aspects. Factors known to play a role in BBTDS include glucosyltransferase (Gtf) polymorphisms of S.mutans and salivary level of mucin MG2. Factors involved in BBTDS caused by S. mutans serotypes c and f are unknown. The present study aimed to detect the risk of caries associated with gtfB and gtfC polymorphisms in S. mutans serotypes c and f, in addition to mucin MG2 levels, in children aged 3-5 years with BBTDS. Methods: This was a cross-sectional study of prospective data on 41 children in a caries-free group and 41 in a caries group. Salivary and plaque samples were collected from for clinical examinations and laboratory analyses. Polymorphisms band detected by PCR analyses and Mucin levels measured in Elisa reader. Results: For the gtfB polymorphism, bands at 700, 800, 1500,and 2000 were an indicator of caries, whereas bands at 500 and 2000 were an indicator of caries in the presence of the gtfC polymorphism. An increase of 0.02 inmucin levels increased the tooth deft score by ±1. Conclusion: S.mutans serotype c and a combination of gtfB and gtfC polymorphisms were associated with the greatest increase in mucin levels. The mucin MG2 level exhibited a significant association with the incidence of caries, S.mutans serotype, and gtf polymorphism.
KW - Baby bottle tooth decay syndrome
KW - Deft
KW - Mucin MG2
KW - Polymorphisms gtfB and gtfC
KW - S. mutans
UR - http://www.scopus.com/inward/record.url?scp=85050245765&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85050245765
SN - 1309-100X
VL - 10
SP - 515
EP - 524
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - Specialissue
ER -