Predicting Gene Interactions in Tumor Microenvironment using Patient Derived Spheroid Primary Cell Culture

Cancer is a heterogenic disease from genetic to individual levels, which induced a variety of
therapheutical research and disease progression. Cancer heterogeneity were also observed in most of
solid tumors including colorectal cancer. Tumor growth depends on intra-tumoral complexity in which
tumor cells surrounded by several cells in their nische known as tumor microenvironment. In this study,
we are using spheroid derived primary culture derived from patients to predict expression pattern of tumor
growth in their microenvironment in vitro. The gene list were data which obtained from our other “on
going publications