PP13 mRNA expression in trophoblasts from preeclamptic placentas

Akihiko Sekizawa, Yuditiya Purwosunu, Shiho Yoshimura, Masamitsu Nakamura, Hanako Shimizu, Takashi Okai, Nicola Rizzo, Antonio Farina

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

To assess the role of placental protein 13 (PP13) in the pathogenesis of preeclampsia, the messenger RNA expression of PP13 was investigated in the trophoblasts from first and third trimester placenta. First, syncytiotrophoblasts and extravillous trophoblasts were separated from frozen section of third trimester placenta obtained from pregnant women with and without preeclampsia by laser microdissection. The PP13 levels of syncytiotrophoblasts were significantly higher than those of extravillous trophoblasts. The expression levels in syncytiotrophoblasts from the preeclampsia were significantly lower than those from normal. Next, the PP13 expression was assessed in trophoblasts from residual samples of chorionic villus sampling at 11 weeks of gestation, who subsequently developed preeclampsia. The levels in the preeclampsia group were significantly lower than those of normal cases. These findings indicate that an alteration in the PP13-messenger RNA expression in the trophoblasts may be associated with the pathogenesis of preeclampsia.

Original languageEnglish
Pages (from-to)408-413
Number of pages6
JournalReproductive Sciences
Volume16
Issue number4
DOIs
Publication statusPublished - 1 Apr 2009

Keywords

  • mRNA expression
  • PP13
  • Preeclampsia.
  • Trophoblast

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