Potency biomarker effect of endothelial microparticles (emps) for early prediction of cardiovascular risk in shift worker nurses

Ike Rahmawaty Alie, Hananto Andriantoro, Ina S. Timan, Astrid Widajati Sulistomo, Ermita Isfandiary Illyas, Muchtaruddin Mansyur

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. Shift work results in changing worker's behavior, food, and sleep patterns, which can cause circadian rhythm disturbance, which is a cardiovascular risk. Until now, a biomarker of early prediction of cardiovascular risk on shift workers is still not developed. This study aimed to assess the cardiovascular risk of shift worker nurses by detecting endothelial microparticles (EMPs). Methods. This longitudinal study compared six shift nurses and five non-shift nurses by measuring the EMPs using antigen CD31+ flow cytometry. All met the inclusion criteria consisting of 28 blood samples followed in one week shift. Results. EMPs among non-shift nurses were below 200 μL. However, shift nurses' EMPs increased above 200 μL with Man-Whitney U p = 0.000 on days 4 and 7 following a one shift per week schedule. Conclusion. There was an increase in shift workers' endothelial microparticles (EMP) which was a sign of cardiovascular risk.

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalActa Medica Philippina
Volume55
Issue number6
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Cardiovascular risk
  • CD31+
  • Endothelial microparticles (EMPs)
  • Nurse
  • Shift work

Fingerprint

Dive into the research topics of 'Potency biomarker effect of endothelial microparticles (emps) for early prediction of cardiovascular risk in shift worker nurses'. Together they form a unique fingerprint.

Cite this