TY - GEN
T1 - Possible Molecular Mechanisms of SARS-CoV-2 Infection in Saliva
AU - Natassya, Priska
AU - Soedarsono, Nurtami
AU - Suhartono, Antonius Winoto
AU - Auerkari, Elza Ibrahim
N1 - Publisher Copyright:
© 2022 American Institute of Physics Inc.. All rights reserved.
PY - 2022/8/16
Y1 - 2022/8/16
N2 - Inhalation of droplets through coughing, sneezing, or even talking can induce direct transmission of SARS-CoV-2 from person to person, and contact with the nose, eyes, and oral mucosa can also cause transmission. Compared with nasopharyngeal specimens, the matching rate of saliva to respiratory viruses (including Coronavirus) is as high as 90%. Coronavirus is only found in the saliva of some individuals but not in nasopharyngeal inhalation. Viruses come from many sources: saliva, nasopharyngeal secretions, and respiratory secretions. The goal of this study is to figure out what the molecular mechanism of SARS-CoV-2 infection through saliva is. This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. In SARS-CoV-2, the glycoprotein found in the viral envelope spikes binds to cell receptors in the form of ACE2. SARS-CoV-2 infection of the salivary glands is a potential since ACE2 is expressed in the salivary glands. Saliva also contains IgA, which can be used as a biomarker for high-risk patients. SARS-CoV-2 infection is detected using IgA, IgM, and IgG antibodies. Saliva samples are also more sensitive than nasopharyngeal swabs. The combined use of saliva samples and nasopharyngeal swabs is also conducive to a more accurate diagnosis. The probable molecular mechanism of SARS-CoV-2 infection from saliva may be deduced from the above statement.
AB - Inhalation of droplets through coughing, sneezing, or even talking can induce direct transmission of SARS-CoV-2 from person to person, and contact with the nose, eyes, and oral mucosa can also cause transmission. Compared with nasopharyngeal specimens, the matching rate of saliva to respiratory viruses (including Coronavirus) is as high as 90%. Coronavirus is only found in the saliva of some individuals but not in nasopharyngeal inhalation. Viruses come from many sources: saliva, nasopharyngeal secretions, and respiratory secretions. The goal of this study is to figure out what the molecular mechanism of SARS-CoV-2 infection through saliva is. This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. In SARS-CoV-2, the glycoprotein found in the viral envelope spikes binds to cell receptors in the form of ACE2. SARS-CoV-2 infection of the salivary glands is a potential since ACE2 is expressed in the salivary glands. Saliva also contains IgA, which can be used as a biomarker for high-risk patients. SARS-CoV-2 infection is detected using IgA, IgM, and IgG antibodies. Saliva samples are also more sensitive than nasopharyngeal swabs. The combined use of saliva samples and nasopharyngeal swabs is also conducive to a more accurate diagnosis. The probable molecular mechanism of SARS-CoV-2 infection from saliva may be deduced from the above statement.
KW - ACE 2
KW - IgA
KW - Molecular
KW - Pathogenesis
KW - Saliva
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85138277208&partnerID=8YFLogxK
U2 - 10.1063/5.0097978
DO - 10.1063/5.0097978
M3 - Conference contribution
AN - SCOPUS:85138277208
T3 - AIP Conference Proceedings
BT - 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Rahman, Siti Fauziyah
A2 - Zakiyuddin, Ahmad
A2 - Whulanza, Yudan
A2 - Intan, Nurul
PB - American Institute of Physics Inc.
T2 - 6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Y2 - 7 July 2021 through 8 July 2021
ER -