POS-663 THE RELATIONSHIP BETWEEN HYPERHYDRATION AND ENDOTHELIAL DYSFUNCTION IN CHRONIC RENAL FAILURE PATIENTS UNDERGOING HEMODIALYSIS TWICE A WEEK

Background: Hyperhydration leads to increased cardiac volume load, blood pressure, left ventricular hypertrophy, pulmonary edema, congestive heart failure. Hemodialysis that is not adequately causes hyperhydration, increased morbidity and mortality of cardiovascular disease. Prolonged hyperhydration causes coronary ischemia due to heart dilation, left ventricular hypertrophy, hypertension, decrease in coronary reserves. Hyperhydration causes excessive systemic vasoconstriction, decreased perfusion of peripheral tissues. Endothelial dysfunction plays a role in excessive vasoconstriction pada hyperhydration. Brain-type natriuretic peptide (BNP) is a parameter for measuring hyperhydration. Asymmetrical dimethyl arginine (ADMA) is an endogenous inhibitor, competitive against endothelial nitric oxide synthase and used as a parameter of endothelial dysfunction. Purpose: Knowing the relationship of hyperhydration with endothelial dysfunction.
Methods: This study is a cross-sectional study in hemodialysis patients twice a week. By using BNP and ADMA as parameters
Results: Of the 126 subjects, hyperhydration proportion (BNP>356 pg/ml) of 64.3%. Median age 52 (47-62) with presumptive causes of primary GGK is hypertension (38.9%), DM (28.6%), Glomerulonephritis (21.4%). There is no significant association between hyperhydration and endothelial dysfunction (PR=1,042, p=0.832 CI 95%=0.714-1.521).
Conclusions: There is no relationship between hyperhydration and endothelial dysfunction (PR=1,042, p=0.832 CI 95%=0.714-1.521).
No conflict of interest