Abstract
Introduction
Hemoglobin variability (Hb-var) is recognized as a predictor of poor clinical outcomes in Chronic Kidney Disease patients. However, factors that influence Hb-var are not well understood. This study aims to investigate the factors that influence Hb-var in CKD-HD patients in Indonesia.
Methods
This is a prospective cohort study conducted in Dialysis Unit-Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia from February-September 2019. All chronic hemodialysis patients aged ≥18 years old were recruited. Hemoglobin (Hb) level and reticulocyte-hemoglobin equivalent (ret-HE) were measured every 4 weeks until 24 weeks of follow up. Hb-var was calculated as the residual standard of deviation, and value ≥1.0 was considered as high.
Results
Out of 127 subjects were included in the analysis. Our study showed that median of haemoglobin levels in HD patients was 9.7 g/dL and the median of HbVar was 0.98+0.60 (min:0.16, max:2.1) g/dL with 47.24% of them had HbVar above 1 g/dL. The median of HbVar level was higher in those who had history of blood transfusion, and the level of HbVar correlate with ESA-dosage, Ret-HE and CRP level in CKD-HD patients who had not had history of blood transfusion during observation.
Hemoglobin variability (Hb-var) is recognized as a predictor of poor clinical outcomes in Chronic Kidney Disease patients. However, factors that influence Hb-var are not well understood. This study aims to investigate the factors that influence Hb-var in CKD-HD patients in Indonesia.
Methods
This is a prospective cohort study conducted in Dialysis Unit-Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia from February-September 2019. All chronic hemodialysis patients aged ≥18 years old were recruited. Hemoglobin (Hb) level and reticulocyte-hemoglobin equivalent (ret-HE) were measured every 4 weeks until 24 weeks of follow up. Hb-var was calculated as the residual standard of deviation, and value ≥1.0 was considered as high.
Results
Out of 127 subjects were included in the analysis. Our study showed that median of haemoglobin levels in HD patients was 9.7 g/dL and the median of HbVar was 0.98+0.60 (min:0.16, max:2.1) g/dL with 47.24% of them had HbVar above 1 g/dL. The median of HbVar level was higher in those who had history of blood transfusion, and the level of HbVar correlate with ESA-dosage, Ret-HE and CRP level in CKD-HD patients who had not had history of blood transfusion during observation.
| Original language | English |
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| Pages | S270 |
| DOIs | |
| Publication status | Published - 1 Apr 2021 |
| Event | ISN World Congress of Nephrology (WCN) Abstracts - Duration: 15 Apr 2021 → 19 Apr 2021 |
Conference
| Conference | ISN World Congress of Nephrology (WCN) Abstracts |
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| Period | 15/04/21 → 19/04/21 |