Poor oocytes increase the risk of aneuploidy embryos

Hilma Putri Lubis, Budi Wiweko, Pritta Ameilia Iffanolida, Kresna Mutia, Oki Riayati, Eliza Mansyur

Research output: Contribution to journalArticle

Abstract

Introduction: Aneuploidy (trisomy or monosomy) is the most commonly identified chromosome abnormality in humans, occurring in at least 5% of all clinically recognized pregnancies and the main genetic cause of miscarriages and congenital birth defects following both natural conception and in vitro fertilization (IVF). There is increasing evidence that the oocyte is the major contributor to embryo aneuploidy, especially in women with advanced reproductive age. The aim of the study is to evaluate the aneuploidy rate in embryos obtained from normal morphological oocytes and dysmorphism oocytes using Preimplantation Genetic Screening (PGS). Methods: A prospective analysis was performed on 20 oocytes and 20 embryos who had undergone preimplantation genetic screening at Yasmin IVF Clinic. Oocyte and embryo quality were assessed based on morphological features. One blastomere from each embryo was analyzed for abnormalities by using array-Comparative Genomic Hybridization (a-CGH). Results: The highest incidence of aneuploidy embryo was observed in poor oocyte quality (100%) followed by moderate oocyte (80%) and good oocyte quality (71.4%) while chaotic pattern oocyte obviously aneuploidy (100%). Conclusion: Women with poor oocyte quality are at risk for developing aneuploidy embryos compared with moderate and good oocyte quality. Therefore, genetic counseling is strongly recommended for woman with poor oocyte quality.

Original languageEnglish
Pages (from-to)6866-6870
Number of pages5
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Aneuploidy
  • Oocyte dysmorphism
  • Oocyte quality
  • Preimplantation genetic screening

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    Lubis, H. P., Wiweko, B., Iffanolida, P. A., Mutia, K., Riayati, O., & Mansyur, E. (2017). Poor oocytes increase the risk of aneuploidy embryos. Advanced Science Letters, 23(7), 6866-6870. https://doi.org/10.1166/asl.2017.9419