Polymorphism of Cyp1a1 (T6235C) is not a significant risk factor of osteoporosis in postmenopausal Indonesian woman

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Abstract

Osteoporosis is an increasingly common disease resulting in reduced bone mineral density (BMD) and elevated likelihood of bone fracture, and particularly affected are postmenopausal women with additional risk factors including genetic predisposition. The CYP1A1, is one of the candidate genes that have been suggested to be associated with the pathogenesis of osteoporosis. This work aimed to evaluate the distribution of a selected polymorphism of this gene (T6235C) with respect to the BMD status in postmenopausal Indonesian women. The results show that osteoporosis is associated with age and menopause, as expected, but not with the tested polymorphism of CYP1A1 in the Indonesian sample population. It is suggested that other P450 cytochrome enzymes and their polymorphisms could provide more significant indicators of the future health of postmenopausal women.

Original languageEnglish
Article number012060
JournalJournal of Physics: Conference Series
Volume1025
Issue number1
DOIs
Publication statusPublished - 30 May 2018
Event7th International Seminar on New Paradigm and Innovation on Natural Sciences and Its Application, ISNPINSA 2017 - Semarang, Indonesia
Duration: 17 Oct 201717 Oct 2017

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