Polymorphism of Apolipoprotein e (APOE) gene in head and neck cancer

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Abstract

One of the risk factors for head and neck cancer (HNC) is genetics. Apolipoprotein E (APOE) polymorphism is known for affecting antioxidant activity which counteracts free radicals triggering cancer pathogenesis. The primary goal is to assess any relationship between APOE polymorphism and HNC. The study is a descriptive research using analytic laboratory. Samples were obtained from Oral Biology Laboratory Faculty of Dentistry, University of Indonesia. The DNA used for evaluation consisted of 50 samples from patients with head and neck cancer and 50 controls. Polymorphism was identified using PCR-RFLP technique. As the result of the research, there are 100% polymorphisms in HNC and control groups. Fisher test results for genotype shows p=0,356 where the cancer group were 50 individuals with heterozygotes, 76% of individuals with the genotype ϵ2 / ϵ3, while 24% of individuals with the ϵ3 / ϵ4 genotype. There was no individual with homozygous genotypes wild type ϵ3 / ϵ3. In the control group, 49 individuals gained heterozygotes and 1 individual had homozygous genotypes. 80% of the control individuals had the genotype ϵ2 / ϵ3, 18% had the ϵ3 / ϵ4 genotype, and 2% with the ϵ4 / ϵ4 gene. Genotype distribution does not match Hardy-Weinberg equilibrium because the p value was less than 0.05. In conclusion, there was a relationship between APOE polymorphism and HNC as a reverse causality but there was no significant difference between APOE polymorphism and HNC.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • Apolipoprotein E
  • genetic polymorphism
  • head and neck cancer

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