Poly(methyl orange)-modified NiO/MoS2/SPCE for a non-enzymatic detection of cholesterol

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14 Citations (Scopus)


A novel modified electrode has been successfully constructed using nanocomposites consisting of nickel oxide (NiO) and molybdenum disulfide (MoS2) immobilized on the surface of a screen-printed carbon electrode (SPCE) for non-enzymatic cholesterol detection. Poly(methyl orange) was also immobilized on this electrode surface to act as the cholesterol-identifying agent. The electrochemical activity of the modified electrode toward cholesterol through differential pulse voltammetry showed a linear response (r2 = 0.9998) in the cholesterol concentration ranges from 1 to 15 mg/dL with a limit of detection of 0.24 mg/dL, a limit of quantification of 0.81 mg/dL and sensitivity of 7.95 × 10−6 A mg−1 dL−1 cm−2. Moreover, this sensor was successfully applied for the quantitative analysis of cholesterol in milk and yogurt samples. Validation using gas chromatography showed an excellent similarity value of 95.2–97.1%.

Original languageEnglish
Article number100285
Publication statusPublished - Sept 2021


  • Cholesterol
  • Differential pulse voltammetry
  • Methyl orange
  • NiO/MoS
  • Non-enzymatic sensor


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