Polyion complex of chitosan and sodium hyaluronate as an implant device for insulin delivery

Silvia Surini, H. Akiyama, M. Morishita, K. Takayama, T. Nagai

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13 Citations (Scopus)


Since polyion complexation apparently occurs between chitosan (CS) and sodium hyaluronate (HA), it may be useful in the preparation of sustained-release devices. Thus, the polyion complex, formed by mixing CS and HA for insulin implant delivery, was used. In this study, we prepared the CS-HA pellets in three mixing ratio and pellet weight combinations, and performed, in addition, in vitro and in vivo release studies. Insulin release from the pellets followed an apparent zero-order mechanism, and could be controlled by the polymer mixing ratio and total weight of the pellets. The rats implanted with the CS-HA pellet containing insulin showed post-implantation hypoglycemic effects for several days, dependent on the CS-HA formulation. Both in vitro and in vivo studies suggested that the CS-HA implant could be a candidate in the development of the protein delivery systems.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalS.T.P. Pharma Sciences
Issue number4
Publication statusPublished - Jul 2003


  • Chitosan
  • Implant
  • Insulin delivery
  • Polyion-complex
  • Sodium hyaluronate


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