Since polyion complexation apparently occurs between chitosan (CS) and sodium hyaluronate (HA), it may be useful in the preparation of sustained-release devices. Thus, the polyion complex, formed by mixing CS and HA for insulin implant delivery, was used. In this study, we prepared the CS-HA pellets in three mixing ratio and pellet weight combinations, and performed, in addition, in vitro and in vivo release studies. Insulin release from the pellets followed an apparent zero-order mechanism, and could be controlled by the polymer mixing ratio and total weight of the pellets. The rats implanted with the CS-HA pellet containing insulin showed post-implantation hypoglycemic effects for several days, dependent on the CS-HA formulation. Both in vitro and in vivo studies suggested that the CS-HA implant could be a candidate in the development of the protein delivery systems.
|Number of pages||4|
|Journal||S.T.P. Pharma Sciences|
|Publication status||Published - 1 Jul 2003|
- Insulin delivery
- Sodium hyaluronate