TY - JOUR
T1 - Polyalcohols as Hydrogen-Bonding Donors in Choline Chloride-Based Deep Eutectic Solvents for Extraction of Xanthones from the Pericarp of Garcinia mangostana L.
AU - Mulia, Kamarza
AU - Fauzia, Farah
AU - Krisanti, Elsa Anisa
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019/2/12
Y1 - 2019/2/12
N2 - Mangosteen (Garcinia mangostana L.) is a fruit that is rich in xanthones, utilized as health supplements or additives in food products due to their high antioxidant activities. Choline chloride (ChCl)-based deep eutectic solvents (DESs) with polyalcohols (ethylene glycol, glycerol, propanediols, and butanediols) as hydrogen bonding donors (HBDs) were used to extract the xanthones from the pericarp of mangosteen. DESs with 1,2-propanediol, 1,3-propanediol, and 1,2-butanediol as HBDs (ChCl to HBD mole ratio of 1:3) afforded the highest extraction yields (2.40-2.63%) of α-mangostin, the most abundant component that represents xanthones. These DESs have intermediate Nile Red polar parameter values similar to that of ethanol and provide extraction yields with a quadratic dependence on the polar parameter. Polarity and viscosity, the important physicochemical properties to consider in the selection of DES as an extraction solvent, could be adjusted based on the consideration of the molecular structure of the polyalcohols. The following factors qualifies the ChCl-1,2-propanediol DES as a designer solvent for green extraction: It is selected from a set of DESs having a homologous class of HBDs to deliver the highest α-mangostin extraction yield, its extract composition similar to that obtained using ethanol, it has low or negligible vapor pressure, both of its components are generally recognized as safe chemicals so that direct utilization of a DES extract is possible, and this DES is used for utilization of agricultural waste products as the resource of bioactive compounds.
AB - Mangosteen (Garcinia mangostana L.) is a fruit that is rich in xanthones, utilized as health supplements or additives in food products due to their high antioxidant activities. Choline chloride (ChCl)-based deep eutectic solvents (DESs) with polyalcohols (ethylene glycol, glycerol, propanediols, and butanediols) as hydrogen bonding donors (HBDs) were used to extract the xanthones from the pericarp of mangosteen. DESs with 1,2-propanediol, 1,3-propanediol, and 1,2-butanediol as HBDs (ChCl to HBD mole ratio of 1:3) afforded the highest extraction yields (2.40-2.63%) of α-mangostin, the most abundant component that represents xanthones. These DESs have intermediate Nile Red polar parameter values similar to that of ethanol and provide extraction yields with a quadratic dependence on the polar parameter. Polarity and viscosity, the important physicochemical properties to consider in the selection of DES as an extraction solvent, could be adjusted based on the consideration of the molecular structure of the polyalcohols. The following factors qualifies the ChCl-1,2-propanediol DES as a designer solvent for green extraction: It is selected from a set of DESs having a homologous class of HBDs to deliver the highest α-mangostin extraction yield, its extract composition similar to that obtained using ethanol, it has low or negligible vapor pressure, both of its components are generally recognized as safe chemicals so that direct utilization of a DES extract is possible, and this DES is used for utilization of agricultural waste products as the resource of bioactive compounds.
KW - Choline chloride
KW - Deep eutectic solvent
KW - Garcinia mangostana L
KW - Mangosteen
KW - Polyalcohol
KW - Solvent extraction
KW - α-mangostin
UR - http://www.scopus.com/inward/record.url?scp=85061538476&partnerID=8YFLogxK
U2 - 10.3390/molecules24030636
DO - 10.3390/molecules24030636
M3 - Article
C2 - 30759720
AN - SCOPUS:85061538476
SN - 1420-3049
VL - 24
JO - Molecules
JF - Molecules
IS - 3
M1 - 636
ER -