POLA MIKROBA, SENSITIVITAS ANTIBIOTIK, DAN KELUARAN JANGKA PENDEK ABSES SEREBRI DI RSUPN CIPTO MANGUNKUSUMO

Introduction : In general, the management of cerebral abscess is combination of antibiotics and operative. Empirical therapy of antibiotics need epidemiology data of the most common cerebral abscess microbes. Isolation technic improvement has facilitated the identification of microbes easily to increase the recovery rate and to decrease the mortality rate. Aim : To know the microbiological pattern, antibiotics sensitivity and cerebral abscess short-term outcome of HIV-negative patients. Method : A retrospective study of HIV-negative patients with cerebral abscesses in RSUPN Cipto Mangunkusumo (RSCM) during August 2010-August 2011. Besides death or survived, KPS (Kanofsky Performance Scale) was used to determine patients outcome. Result : From 11 collected cases, 5 cases underwent surgery and the etiologic agent can be identified, one case of post operative, and one case from brain biopsy. Nine of the 10 cases got a combination of ceftriaxon and metronidazol with the output 6 were survived and 3 were died. One patient with otogenic cerebral abscess who got single meropenem treatment was died, whereas patients with tuberculosis cerebral abscess got antituberculosis therapy (OAT) and still survived. Of the 11 patients, four (36.4%) died (3 otogenic, post operative), one was loss to follow-up, six survived with outcome 3 months post admission KPS 70-100. Conclusions : The most common microbe of cerebral abscess in HIV-negative patients at RSCM is Pseudomonas sp. and Streptococcus (pyogenic). Third-generation cephalosporin (ceftriaxon) is still sensitive to most of these patients. The combination of ceftriaxon and metronidazol are still a good preference of antibiotics for bacterial cerebral abscess which provide good outcome..