Pneumocystis pneumonia with atypical presentation in an HIV seronegative patient with systemic lupus erythematosus during steroid therapy

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Abstract

Pneumocystis pneumonia (PCP) is common among HIV patients, but it is rare in patients with autoimmune diseases such as systemic lupus erythematosus (SLE). Some of the risk factors related to PCP in SLE patients include a high steroid dose, greater disease activity, renal involvement, and lower lymphocyte and CD4+ counts. Described herein is the case of a 23- year-old female with SLE who was treated with highdose steroid therapy. She was admitted to the clinic with a dry cough and a prolonged fever persisting since the tapering of the steroid dose. High-resolution computed tomography of the thorax revealed intraseptal thickening, subpleural nodules, and enlargement of the 4L, 6, and 7 lymph nodes. A laboratory examination of an induced sputum sample using polymerase chain reaction was positive for Pneumocystis jirovecii. Trimethoprim / sulfamethoxazole was administered for 14 days and clinical improvement was observed.
Original languageEnglish
Pages (from-to)82-85
JournalRespiratory Case Reports
Volume7
Issue number2
DOIs
Publication statusPublished - 22 Jan 2018

Keywords

  • CD4 lymphocyte
  • pneumocystis pneumonia
  • systemic lupus erythematosus

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