TY - JOUR
T1 - Plasma 3-nitrotyrosine, urinary 8-isoprostane and 8-OHdG among healthy Japanese people
AU - Sakano, Noriko
AU - Takahashi, Noriko
AU - Wang, Da Hong
AU - Sauriasari, Rani
AU - Takemoto, Kei
AU - Kanbara, Sakiko
AU - Sato, Yoshie
AU - Takigawa, Tomoko
AU - Takaki, Jiro
AU - Ogino, Keiki
N1 - Funding Information:
This work was supported in part by funding from the Junpukai and in part from Health Science Center Foundation. We gratefully acknowledge the technical contribution from Dr Bingling Wang and Ms A. Ohashi.
PY - 2009
Y1 - 2009
N2 - To examine the relation between lifestyle factors and oxidative stress biomarkers, this study analysed plasma 3-nitrotyrosine (3-NT), urinary 8-isoprostane and 8-hydroxy-2′-deoxyguanosine (8-OHdG) of 323 healthy Japanese without any disease. Plasma 3-NT was significantly increased by excessive exercise (p=0.010), but it was not significantly different in terms of sex, age (< 40, ≥40), BMI (<18.5, 18.5-24.9, ≥25.0), smoking (non-smokers, smokers) and alcohol drinking per week (non-drinkers, <10 units, ≥10 units). Urinary 8-isoprostane was significantly associated with alcohol drinking (p<0.01) and sex (p<0.01), although it had no significant relevance to age and exercise. Moreover, urinary 8-OHdG was positively associated with age (p<0.05) and negatively associated with BMI (p<0.05) and fasting insulin (p<0.001). However, it was not related with sex, smoking, alcohol drinking and exercise. In conclusion, the present results suggest that 3-NT, 8-isoprostane and 8-OHdG seem to be useful biomarkers for early prediction of lifestyle-related disease risk at the population level.
AB - To examine the relation between lifestyle factors and oxidative stress biomarkers, this study analysed plasma 3-nitrotyrosine (3-NT), urinary 8-isoprostane and 8-hydroxy-2′-deoxyguanosine (8-OHdG) of 323 healthy Japanese without any disease. Plasma 3-NT was significantly increased by excessive exercise (p=0.010), but it was not significantly different in terms of sex, age (< 40, ≥40), BMI (<18.5, 18.5-24.9, ≥25.0), smoking (non-smokers, smokers) and alcohol drinking per week (non-drinkers, <10 units, ≥10 units). Urinary 8-isoprostane was significantly associated with alcohol drinking (p<0.01) and sex (p<0.01), although it had no significant relevance to age and exercise. Moreover, urinary 8-OHdG was positively associated with age (p<0.05) and negatively associated with BMI (p<0.05) and fasting insulin (p<0.001). However, it was not related with sex, smoking, alcohol drinking and exercise. In conclusion, the present results suggest that 3-NT, 8-isoprostane and 8-OHdG seem to be useful biomarkers for early prediction of lifestyle-related disease risk at the population level.
KW - 3-Nitrotyrosine
KW - 8-OHdG
KW - 8-isoprostane
KW - Biomarkers
KW - Lipid peroxidation
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=60349106643&partnerID=8YFLogxK
U2 - 10.1080/10715760802663124
DO - 10.1080/10715760802663124
M3 - Article
C2 - 19204871
AN - SCOPUS:60349106643
SN - 1071-5762
VL - 43
SP - 183
EP - 192
JO - Free Radical Research
JF - Free Radical Research
IS - 2
ER -