Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria

Sukma Oktavianthi, Muhammad Fauzi, Leily Trianty, Hidayat Trimarsanto, Anom Bowolaksono, Rintis Noviyanti, Safarina G. Malik

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalPlacenta
Volume80
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • Birth weight
  • mtDNA copy number
  • Placental malaria
  • Relative telomere length

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