TY - JOUR
T1 - Pirinç kepeği takviyesi, karbon tetraklorürle İndüklenen sıçanların testis ve karaciğerinde gsh seviyelerini artırır
AU - Gunarti, Dwirini Retno
AU - Sukmawati, Dewi
AU - Nasser, Mochammad Kamal
AU - Ikram, Teuku Abdi Zil
AU - Pribawa, Rizqi Nanda
AU - Suryandari, Dwi Anita
N1 - Funding Information:
This study was supported by a research grant (Hibah PITTA B 2019, No. NKB-0530/UN2.R3.1/ HKP.05.00/2019) funded by the Directorate of Research and Community Engagement, Universitas Indonesia. Authors convey their appreciation to laboratory staff in the Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia for technical assistance during the experiments.
Publisher Copyright:
© 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
PY - 2021
Y1 - 2021
N2 - In the present study, the potency of rice bran as an antioxidant was examined. Rice bran is a by-product of the rice milling process, despite being a rich nutrient, it has limitations in food application. In this study, we used carbon tetrachloride-induced rats (CCl4) as a model of oxidative stress and examined the effect of extract IPB 3S rice bran supplement (RBS) on testis and liver endogenous antioxidant. The testis and liver were used as the representative organs which prone to exposure to reactive oxygen species (ROS). We used 150 and 300 mg.kg-1 Body weight (BW) of RBS. The Concentration of glutathione (GSH) in both organs was measured. All groups administered by RBS had significantly higher GSH levels compared to the CCl4 group, both in testis and liver. The dose of 300 mg.kg-1 BW RBS had a significantly higher GSH level in testis, while 150 mg.kg-1 VA RBS had a significantly higher GSH level in the liver tissue compared to the control group accordingly. Thus, the rice bran supplement enhances GSH levels in rat’s liver and testis which potentially has protective effects.
AB - In the present study, the potency of rice bran as an antioxidant was examined. Rice bran is a by-product of the rice milling process, despite being a rich nutrient, it has limitations in food application. In this study, we used carbon tetrachloride-induced rats (CCl4) as a model of oxidative stress and examined the effect of extract IPB 3S rice bran supplement (RBS) on testis and liver endogenous antioxidant. The testis and liver were used as the representative organs which prone to exposure to reactive oxygen species (ROS). We used 150 and 300 mg.kg-1 Body weight (BW) of RBS. The Concentration of glutathione (GSH) in both organs was measured. All groups administered by RBS had significantly higher GSH levels compared to the CCl4 group, both in testis and liver. The dose of 300 mg.kg-1 BW RBS had a significantly higher GSH level in testis, while 150 mg.kg-1 VA RBS had a significantly higher GSH level in the liver tissue compared to the control group accordingly. Thus, the rice bran supplement enhances GSH levels in rat’s liver and testis which potentially has protective effects.
KW - Antioxidants
KW - CCl4
KW - Glutathione
KW - IPB 3S
KW - Liver
KW - Rice bran
KW - Testis
UR - http://www.scopus.com/inward/record.url?scp=85110108277&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85110108277
SN - 1300-4182
VL - 46
SP - 129
EP - 138
JO - Fabad Journal of Pharmaceutical Sciences
JF - Fabad Journal of Pharmaceutical Sciences
IS - 2
ER -