TY - JOUR
T1 - Phytosynthesis of [198Au]Au@SiO2 core–shell nanoparticles for potential radio-photothermal therapy
AU - Fikri, Ahsanal
AU - Pertiwi, Ligwina Dita
AU - Forentin, Alfian Mahardika
AU - Sari, Dian Maya
AU - Juliyanto, Sumandi
AU - Putra, Amal Rezka
AU - Susilo, Veronika Yulianti
AU - Febrian, Muhamad Basit
AU - Setiawan, Herlan
AU - Pujiyanto, Anung
AU - Ritawidya, Rien
AU - Yulizar, Yoki
N1 - Publisher Copyright:
© Akadémiai Kiadó, Budapest, Hungary 2024.
PY - 2024
Y1 - 2024
N2 - [198Au]Au@SiO2 core–shell nanoparticles ([198Au]Au@SiO2 CSNPs) were synthesized using Persea americana Mill. seed (PAS) extract as a reducing agent. The synthesis involves amino-functionalized SiO2 core formation followed by shell formation with [198Au]Au seeds attachment and a reduction process. The resulting [198Au]Au@SiO2 CSNPs, sized at 188.96 nm, exhibited near-infrared (NIR) absorption at 750 nm and radiochemical purity of 99.91%. In vitro treatment, combined with 980 nm laser irradiation at 3 W cm−2, induced hyperthermia, enhancing cell death in LNCaP cancer cells to 2.60% viability. This study highlights the potential of [198Au]Au@SiO2 CSNPs as a promising radio-photothermal therapeutic agent.
AB - [198Au]Au@SiO2 core–shell nanoparticles ([198Au]Au@SiO2 CSNPs) were synthesized using Persea americana Mill. seed (PAS) extract as a reducing agent. The synthesis involves amino-functionalized SiO2 core formation followed by shell formation with [198Au]Au seeds attachment and a reduction process. The resulting [198Au]Au@SiO2 CSNPs, sized at 188.96 nm, exhibited near-infrared (NIR) absorption at 750 nm and radiochemical purity of 99.91%. In vitro treatment, combined with 980 nm laser irradiation at 3 W cm−2, induced hyperthermia, enhancing cell death in LNCaP cancer cells to 2.60% viability. This study highlights the potential of [198Au]Au@SiO2 CSNPs as a promising radio-photothermal therapeutic agent.
KW - Cancer cells
KW - Core–shell
KW - Gold nanoparticles
KW - Phytosynthesis
KW - Radio-photothermal therapy
KW - Silica nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85194578071&partnerID=8YFLogxK
U2 - 10.1007/s10967-024-09549-9
DO - 10.1007/s10967-024-09549-9
M3 - Article
AN - SCOPUS:85194578071
SN - 0236-5731
VL - 333
SP - 3807
EP - 3817
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
IS - 8
ER -