Phytosynthesis of [198Au]Au@SiO2 core–shell nanoparticles for potential radio-photothermal therapy

Ahsanal Fikri, Ligwina Dita Pertiwi, Alfian Mahardika Forentin, Dian Maya Sari, Sumandi Juliyanto, Amal Rezka Putra, Veronika Yulianti Susilo, Muhamad Basit Febrian, Herlan Setiawan, Anung Pujiyanto, Rien Ritawidya, Yoki Yulizar

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

[198Au]Au@SiO2 core–shell nanoparticles ([198Au]Au@SiO2 CSNPs) were synthesized using Persea americana Mill. seed (PAS) extract as a reducing agent. The synthesis involves amino-functionalized SiO2 core formation followed by shell formation with [198Au]Au seeds attachment and a reduction process. The resulting [198Au]Au@SiO2 CSNPs, sized at 188.96 nm, exhibited near-infrared (NIR) absorption at 750 nm and radiochemical purity of 99.91%. In vitro treatment, combined with 980 nm laser irradiation at 3 W cm−2, induced hyperthermia, enhancing cell death in LNCaP cancer cells to 2.60% viability. This study highlights the potential of [198Au]Au@SiO2 CSNPs as a promising radio-photothermal therapeutic agent.

Original languageEnglish
Pages (from-to)3807-3817
Number of pages11
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume333
Issue number8
DOIs
Publication statusAccepted/In press - 2024

Keywords

  • Cancer cells
  • Core–shell
  • Gold nanoparticles
  • Phytosynthesis
  • Radio-photothermal therapy
  • Silica nanoparticles

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