Phytosynthesis of gold-198 nanoparticles for a potential therapeutic radio-photothermal agent

Sumandi Juliyanto, Ligwina Dita Pertiwi, Ahid Nurmanjaya, Anung Pujiyanto, Herlan Setiawan, Fernanto Rindiyantono, Abidin, Ahsanal Fikri, Amal Rezka Putra, Alfian Mahardika Forentin, Veronika Yulianti Susilo, Muhamad Basit Febrian, Rien Ritawidya, Yoki Yulizar

Research output: Contribution to journalArticlepeer-review

Abstract

We produced spherical gold-198 nanoparticles with an average size of 41 nm, good stability, and high radiochemical purity for a promising single agent of radio-photothermal therapy using Curcuma longa rhizome extract as a reducing and capping agent. The combination of in vitro treatment using gold-198 nanoparticles and irradiation of 980 nm wavelength lasers with a power output of 2 W/cm2 induced hyperthermia temperature and exhibited enhancement of the percentage dead on MDA-MB-123 cancer cells compared to gold-198 nanoparticles alone.

Original languageEnglish
Article number111141
JournalApplied Radiation and Isotopes
Volume204
DOIs
Publication statusPublished - Feb 2024

Keywords

  • Cancer cells
  • Characterization
  • Gold-198 nanoparticles
  • Phytosynthesis
  • Radio-photothermal therapy

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