In this research, we develop Indonesia marine macroalgae of Eucheuma sp. as an anti-breast cancer agent. Macroalgae Eucheuma sp. which was collected from Labuhan Aji beach, Lombok, Nusa Tenggara Barat, Indonesia, were extracted into four different organic solvents, which are n-hexane, ethyl acetate, chloroform and ethanol. The extracts were subjected to Phytochemistry test and were analyzed by Thin Layer Chromatography (TLC). Subsequently, cytotoxic activity of n-hexane, chloroform, ethyl acetate, and ethanol extracts of Eucheuma sp. were evaluated as a growth inhibitor for breast MCF-7 cancer cells. Based on the phytochemical analysis, the extracts of Eucheuma sp. containing secondary metabolite of flavonoid, triterpenoid, alkaloid and tannin, while TLC analysis indicated that the extracts were composed of one to four chemical compounds. Extracts of Eucheuma sp. demonstrated a strong cytotoxic activity against breast MCF-7 cancer cells. The results suggesting that macroalgae Eucheuma sp. should be developed as a promising anti-breast cancer agent.
|Title of host publication||3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices|
|Subtitle of host publication||Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018|
|Editors||Praswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti|
|Publisher||American Institute of Physics Inc.|
|Publication status||Published - 9 Apr 2019|
|Event||3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia|
Duration: 6 Aug 2018 → 8 Aug 2018
|Name||AIP Conference Proceedings|
|Conference||3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018|
|Period||6/08/18 → 8/08/18|
- breast MCF-7 cells
- cytotoxic activity
- Eucheuma sp.
- MTT assay