Phytochemistry test and cytotoxic activity of macroalgae Eucheuma Sp. as a growth inhibitor of breast MCF-7 cancer cells

Elvira Lesmana, Ade Arsianti, Trivani Putri, Priscilla Aya Maheswari Subroto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this research, we develop Indonesia marine macroalgae of Eucheuma sp. as an anti-breast cancer agent. Macroalgae Eucheuma sp. which was collected from Labuhan Aji beach, Lombok, Nusa Tenggara Barat, Indonesia, were extracted into four different organic solvents, which are n-hexane, ethyl acetate, chloroform and ethanol. The extracts were subjected to Phytochemistry test and were analyzed by Thin Layer Chromatography (TLC). Subsequently, cytotoxic activity of n-hexane, chloroform, ethyl acetate, and ethanol extracts of Eucheuma sp. were evaluated as a growth inhibitor for breast MCF-7 cancer cells. Based on the phytochemical analysis, the extracts of Eucheuma sp. containing secondary metabolite of flavonoid, triterpenoid, alkaloid and tannin, while TLC analysis indicated that the extracts were composed of one to four chemical compounds. Extracts of Eucheuma sp. demonstrated a strong cytotoxic activity against breast MCF-7 cancer cells. The results suggesting that macroalgae Eucheuma sp. should be developed as a promising anti-breast cancer agent.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • breast MCF-7 cells
  • cytotoxic activity
  • Eucheuma sp.
  • macroalgae
  • MTT assay
  • phytochemistry

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