TY - JOUR
T1 - Phytochemistry and antioxidant activity of soursop (Annona muricata) leaves
AU - Qorina, Fona
AU - Arsianti, Ade
AU - Fithrotunnisa, Qotrunnada
AU - Tejaputri, Nadzila Anindya
N1 - Funding Information:
We wish to express our gratitude to the Directorate of Research and Public Service (DRPM) and the Faculty of Medicine, University of Indonesia for the research grant of Publikasi Internasional Terindeks Scopus Untuk Tugas Akhir Mahasiswa (PITTA) for the fiscal year 2018.
Funding Information:
This article was presented in the 3rd International Conference and Exhibition on Indonesian Medical Education and Research Institute (ICE on IMERI 2018), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. We thank the 3rd ICE on IMERI Committee who had supported the peer review and manuscript preparation before submitting to the journal. We wish to express our gratitude to the Directorate of Research and Public Service (DRPM) and the Faculty of Medicine, University of Indonesia for the research grant of Publikasi Internasional Terindeks Scopus Untuk Tugas Akhir Mahasiswa (PITTA) for the fiscal year 2018.
Publisher Copyright:
© 2019 The Authors. Published by Innovare Academic Sciences Pvt Ltd.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: Soursop (Annona muricata) is a tropical plant which has been utilized as a folk medicine to treat many diseases including cancer, inflammation and parasitic infection. In this study, we investigated its phytochemistry properties and antioxidant activity against free radicals. Methods: Annona muricata leaves were extracted in three different solvents: Ethanol, ethyl acetate and n-hexane. Afterwards, a phytochemistry test and the thin layer chromatography (TLC) method were used to evaluate bioactive compounds contained in the three different extracts. Antioxidant activity from the semi-polar (ethyl acetate) and polar (ethanol) solvents were evaluated by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and the antioxidant activity is expressed by IC50 value. The results were compared to ascorbic acid as a positive control. Results: The phytochemistry test showed that the extracts were positive for flavonoids, steroids, alkaloids, glycosides and tannins. Moreover, TLC analysis revealed that there were three chemical compounds contained in the extracts. The results from the DPPH method were that ethanolic extract was shown to have the most potent antioxidant activity with an IC50value of 35.51 ppm. Conclusion: The ethanolic extract of Annona muricata could be developed as the next promising natural antioxidant source.
AB - Objective: Soursop (Annona muricata) is a tropical plant which has been utilized as a folk medicine to treat many diseases including cancer, inflammation and parasitic infection. In this study, we investigated its phytochemistry properties and antioxidant activity against free radicals. Methods: Annona muricata leaves were extracted in three different solvents: Ethanol, ethyl acetate and n-hexane. Afterwards, a phytochemistry test and the thin layer chromatography (TLC) method were used to evaluate bioactive compounds contained in the three different extracts. Antioxidant activity from the semi-polar (ethyl acetate) and polar (ethanol) solvents were evaluated by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, and the antioxidant activity is expressed by IC50 value. The results were compared to ascorbic acid as a positive control. Results: The phytochemistry test showed that the extracts were positive for flavonoids, steroids, alkaloids, glycosides and tannins. Moreover, TLC analysis revealed that there were three chemical compounds contained in the extracts. The results from the DPPH method were that ethanolic extract was shown to have the most potent antioxidant activity with an IC50value of 35.51 ppm. Conclusion: The ethanolic extract of Annona muricata could be developed as the next promising natural antioxidant source.
KW - Antioxidants
KW - DPPH method
KW - Phytochemiscals
KW - Soursop
UR - http://www.scopus.com/inward/record.url?scp=85077170509&partnerID=8YFLogxK
U2 - 10.22159/ijap.2019.v11s6.33524
DO - 10.22159/ijap.2019.v11s6.33524
M3 - Article
AN - SCOPUS:85077170509
SN - 0975-7058
VL - 11
SP - 1
EP - 6
JO - International Journal of Applied Pharmaceutics
JF - International Journal of Applied Pharmaceutics
IS - Special Issue 6
ER -
