TY - JOUR
T1 - Phytochemical Screening, Antioxidant Activity, and Anti-Inflammatory Potential of Rhinachantus nasutus (L.) Kurz Flower Ethanol Extract
AU - Irawan, Candra
AU - Elya, Berna
AU - Hanafi, Muhammad
AU - Saputri, Fadlina Chany
N1 - Funding Information:
The Ministry of Research and Technology/National Research and Innovation Agency of Indonesia funded this research with a Doctoral Dissertation Research Grant 2022 [Nomor: 021/E5/PG.02.00.PT/2022 dan 142. /PKS/WRIII-DRP/UI/2022 and NKB-782/UN2.RST/ HKP.05.00/2022].
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PY - 2022/9
Y1 - 2022/9
N2 - Aims: The purpose of this study was to determine the content of the secondary metabolite compound in the flower extract of Rhinachantus nasutus (L.) Kurz (RnK); The potential of the extract as a radical scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH); and its potential as an anti-inflammatory by inhibiting protein denaturation with bovine serum albumin (BSA). Results: Phytochemical screening results on the ethanolic extract of R. nasutus flowers revealed the presence of steroid glycosides, alkaloids, flavonoids, phenolics, and tannins. The extract has a strong ability to scavenge DPPH radicals with an IC50 value of 77.07 ± 0.05 mg/L. Besides that, the ethanol extract has very strong anti-inflammatory activity, with an IC50 value of 13.88 ± 0.2 mg/L. Conclusion: According to these findings, the ethanolic extract of R. nasutus flower can be used as an alternative anti-inflammatory drug.
AB - Aims: The purpose of this study was to determine the content of the secondary metabolite compound in the flower extract of Rhinachantus nasutus (L.) Kurz (RnK); The potential of the extract as a radical scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH); and its potential as an anti-inflammatory by inhibiting protein denaturation with bovine serum albumin (BSA). Results: Phytochemical screening results on the ethanolic extract of R. nasutus flowers revealed the presence of steroid glycosides, alkaloids, flavonoids, phenolics, and tannins. The extract has a strong ability to scavenge DPPH radicals with an IC50 value of 77.07 ± 0.05 mg/L. Besides that, the ethanol extract has very strong anti-inflammatory activity, with an IC50 value of 13.88 ± 0.2 mg/L. Conclusion: According to these findings, the ethanolic extract of R. nasutus flower can be used as an alternative anti-inflammatory drug.
KW - 22-diphenyl-1-picrylhydrazyl
KW - Anti-inflammatory
KW - BSA
KW - RnK
UR - http://www.scopus.com/inward/record.url?scp=85141986958&partnerID=8YFLogxK
U2 - 10.5530/pj.2022.14.129
DO - 10.5530/pj.2022.14.129
M3 - Article
AN - SCOPUS:85141986958
SN - 0975-3575
VL - 14
SP - 521
EP - 526
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 5
ER -