Phosphate concentration in unstimulated saliva of patients with type 2 diabetes mellitus

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Abstract

Patients with type 2 diabetes mellitus (T2DM) are at a high risk of dental caries. Phosphate plays a primary role in the buffer capacity of unstimulated saliva; thus, the concentration of phosphate is associated with individual risk factors for caries. Ketosis and hyperparathyroidism, conditions that frequently develop with T2DM, can reduce the phosphate buffer levels in the body, consequently reducing the concentration of phosphate in unstimulated saliva. The aim of this study is to determine the concentration of unstimulated saliva from patients with type 2 diabetes mellitus (T2DM). Unstimulated saliva samples from fifteen individuals with T2DM and 15 nondiabetic subjects were collected, and the concentration of phosphate was measured using the phosphomolybdate method with an ultraviolet-visible spectrophotometer. There were significant differences in the phosphate concentrations (p < 0.05) in the saliva of the test and control subjects. The phosphate concentration in the unstimulated saliva of patients with type 2 diabetes mellitus (T2DM) (0.27 ± 0.05 mmol/L) is significantly lower than that of individuals without diabetes mellitus (2.16 ± 0.22 mmol/L).

Original languageEnglish
Pages (from-to)1182-1188
Number of pages7
JournalJournal of International Dental and Medical Research
Volume12
Issue number3
Publication statusPublished - 1 Jan 2019

Keywords

  • Buffer capacity
  • Patients
  • Phosphate
  • Phosphate concentration
  • Type 2 Diabetes mellitus
  • Unstimulated saliva

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