Pharmacophore-based virtual screening and molecular docking simulation of flavonoids as smoothened protein inhibitor of Hedgehog signaling pathways

Keyphrases

• Molecular Docking 100%
• Flavonoids 100%
• Pharmacogenetic Testing 100%
• Hedgehog Signaling Pathway 100%
• Proteinase Inhibitor 100%
• Smoothened Protein 100%
• Flavonoid Compounds 50%
• Colorectal Cancer 33%
• Binding Site 33%
• Indonesia 16%
• Mortality Rate 16%
• Methyl 16%
• Common Cancers 16%
• Binding Affinity 16%
• Molecular Interactions 16%
• Cancer Stem Cells 16%
• Docking Simulation 16%
• Drug-likeness 16%
• Phenyl 16%
• Public Health Risk 16%
• Signaling Pathway 16%
• Aromatics 16%
• Pharmacophore 16%
• Pharmacophore Features 16%
• Carboxamide 16%
• Massive Growth 16%
• Molecular Binding 16%
• Binding Mode 16%
• Cancer Formation 16%
• H-donor 16%
• Vismodegib 16%
• Computational Toxicity 16%
• G Protein-coupled Receptor 16%
• Interaction Affinity 16%
• 4H-chromene 16%
• Flavone Compound 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Molecular Docking Simulations 100%
• Virtual Screening 100%
• Flavonoid 100%
• Hedgehog 100%
• Protein Inhibitor 100%
• Smoothened Protein 100%
• Binding Site 28%
• Malignant Neoplasm 28%
• Colorectal Carcinoma 28%
• Mortality Rate 14%
• Carboxamide 14%
• G Protein Coupled Receptor 14%
• Vismodegib 14%
• Flavone 14%

Biochemistry, Genetics and Molecular Biology

• Docking (Molecular) 100%
• Pharmacophore 100%
• Hedgehog Signaling Pathway 100%
• Flavonoid 100%
• Binding Site 28%
• Cancer Stem Cell 14%
• Signal Transduction 14%
• Binding Affinity 14%
• Mortality Rate 14%
• Molecular Interaction 14%
• G Protein Coupled Receptor 14%
• Vismodegib 14%