The purpose of this phenomenology study was to identify the nurse’s and relative’s perception on knowledge and skill needed by the nurses & relatives in caring patient in the hospital and in their house. Ten respondents (5 nurses and 5 relatives of the patients) participated the study. The findings identified knowledge & skill needed by nurses are: (1) knowledge & skill on counseling, (2) Anti Retro Viral therapy & its side effect, (3) universal precaution, (4) symptom management, (5) mental support, and (6) treatment standard on occupational exposure to HIV. The findings from the relative’s are: (1) knowledge on HIV/AIDS and how it spreads (2) knowledge on signs & symptoms of HIV/AIDS, (3) knowledge & skill on universal precaution and (4) symptom management. Some recommendations of the study were proposed that this study should be continued to have some other respondents. The result of these studies could be beneficial to improve the nursing care to the HIV/AIDS patient and their quality of life during AIDS stage, and it could be beneficial to the improvement the effectively of the nursing care of patient with HIV/AIDS.