Periportal CD4+ cell infiltration increases in HIV/hepatitis C virus-coinfected patients commencing ART, whereas CD8+ cells clear from the liver

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Abstract

Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes in the liver are described in a prospective study of HCV-seropositive HIV-infected patients at Cipto Mangunkusomo Hospital (Jakarta, Indonesia). Liver biopsy specimens were collected at baseline (n = 48) and 48 weeks (n = 34). Ishak scores showed mild but detectable inflammation and/ or fibrosis. Levels of portal inflammation declined during ART (P = .03), whereas fibrosis remained (P = .11). Portal infiltration of CD4+ cells increased during ART (P < .0001), whereas infiltration of CD8 + cells subsided. Numbers of CD4+ cells in the liver at baseline correlated with circulating CD4+ T-cell counts (P = .03-.05). Numbers of liver-infiltrating CD4+ and CD8+ cells at baseline were not associates with subsequent experience of an immune restoration disease, which is defined by a rise in alanine transaminase levels during ART.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalJournal of Infectious Diseases
Volume210
Issue number3
DOIs
Publication statusPublished - 1 Aug 2014

Keywords

  • Antiretroviral therapy
  • Co-infection hepatitis C
  • HIV
  • Liver pathology

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