Objective: The aim of the study is to investigate the effect of various dosage forms and substances such as Tretinoin, α-hydroxy acid, Vitamin C and Vitamin E on percutane transport profile of caffeine and aminophylline through rat skin using Franz Diffusion Cell. Methods: Aminophylline and caffein were formulated into three different dosage forms, which were cream, gel, and ointment. Tretinoin, α-hydroxy acid, Vitamin C and Vitamin E were added into formulations as penetration enhancer. All dosage forms were physically evaluated and penetration of active ingredient through the skin were tested. Results: Gel has the highest caffeine and aminophylline penetration followed by cream and ointment. Tretinoin and AHA can enhance the caffeine and aminophylline percutaneous penetration. Vitamin C, Vitamin E and the combination of both substances can enhance the caffeine and aminophylline percutaneous penetration. where Penetration enhancement by vitamin C is higher than penetration enhancement by vitamin E in caffeine penetration, but in aminophylline, penetration enhancement by vitamin E is higher. On the other side, aminophylline penetration on cream containing vitamin C+E combination did not significantly doubled the penetration of each one as caffeine penetration did. Conclusion: The gel is the highest eighth-hour caffeine or aminophylline penetration, followed by cream and ointment. Tretinoin, α-hydroxy acid, Vitamin C and Vitamin E enhanced the eighth-hour caffeine or aminophylline skin penetrations from cream, gel, and ointment. All formulas were physically stable.
|Number of pages||7|
|Journal||International Journal of Pharmacy and Pharmaceutical Sciences|
|Publication status||Published - 1 Jan 2014|
- Percutane transport profile
- Vitamin C and E
- α-hydroxy acid