Percutane transport profile of caffeine and aminophyllin as anticellulite and the influences of other substances on in vitro penetration

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3 Citations (Scopus)

Abstract

Objective: The aim of the study is to investigate the effect of various dosage forms and substances such as Tretinoin, α-hydroxy acid, Vitamin C and Vitamin E on percutane transport profile of caffeine and aminophylline through rat skin using Franz Diffusion Cell. Methods: Aminophylline and caffein were formulated into three different dosage forms, which were cream, gel, and ointment. Tretinoin, α-hydroxy acid, Vitamin C and Vitamin E were added into formulations as penetration enhancer. All dosage forms were physically evaluated and penetration of active ingredient through the skin were tested. Results: Gel has the highest caffeine and aminophylline penetration followed by cream and ointment. Tretinoin and AHA can enhance the caffeine and aminophylline percutaneous penetration. Vitamin C, Vitamin E and the combination of both substances can enhance the caffeine and aminophylline percutaneous penetration. where Penetration enhancement by vitamin C is higher than penetration enhancement by vitamin E in caffeine penetration, but in aminophylline, penetration enhancement by vitamin E is higher. On the other side, aminophylline penetration on cream containing vitamin C+E combination did not significantly doubled the penetration of each one as caffeine penetration did. Conclusion: The gel is the highest eighth-hour caffeine or aminophylline penetration, followed by cream and ointment. Tretinoin, α-hydroxy acid, Vitamin C and Vitamin E enhanced the eighth-hour caffeine or aminophylline skin penetrations from cream, gel, and ointment. All formulas were physically stable.

Original languageEnglish
Pages (from-to)532-538
Number of pages7
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue number5
Publication statusPublished - 1 Jan 2014

Keywords

  • Aminophylline
  • Caffeine
  • Percutane transport profile
  • Tretinoin
  • Vitamin C and E
  • α-hydroxy acid

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