Introduction: EEG is an essential investigative tool for use in people with epilepsy, and up until now still remains central in the diagnosis and classification of epilepsies. The yield of interictal epileptiform discharges (IEDs) can be increased by many activation methods, among them is sleep deprivation. Aim: To determine the important effects of different EEG protocols on the yield of interictal epileptiform discharges in people with possible new epilepsy. Methods: A randomized controlled study was conducted. The population target was all possible new epilepsy patients in the outpatient clinic of dr. Cipto Mangunkusumo Hospital in Jakarta. 44 patients underwent either a non- sleep deprived (NSD) EEG or a sleep deprived (SD) one. Results: Out of 44 possible new epilepsy patients who demonstrated interictal epileptiform discharges SD EEG provoked abnormalities in 77,3% while NSD EEG produced 50% . Within the two groups, the most clinical characteristics are with partial seizure type with onset of seizure < 25 years of age, and seizure frequency more than once a month. SD EEG have the yield of interictal epileptiform discharges 3.67 (95% CI = 0.92-14.66) with p = 0.066 and onset of seizure < 25 years of age has RR = 4.42 (95% CI = 1.07-16.86)with p = 0.040. Conclusion: Sleep deprivation increases the yield of interictal epileptiform discharges. The age of onset < 25 years also increases the yield of IEDs with or without SD EEG.
|Publication status||Published - 2010|