Nurses are at high risk of low back pain (LBP). This study aimed to assess physical activities and working facilities as the risk factors that can lead to LBP in nurses in the wards and the emergency units of several hospitals in Jakarta to provide recommendations for controlling the risk of LBP. Observations were performed to identify high-risk activities and the rapid entire body assessment (REBA) method was used to assess the ergonomic risk. Questionnaires and Nordic body map were also used to assess the other risk factors and LBP-related complaints. In addition, the cross-sectional design for association analysis, measurement and analysis to assess the working tools were also applied. The results showed that the prevalence of LBP among nurses was higher in the RSUD Tarakan emergency unit in 2013 (61.1%) and RS Bhayangkara wards in 2012 (31.8%). In the private hospital emergency unit, the LBP is lower compared to the results of a global survey (43.1–87%). The dominant causes of LBP were bending and patient-lifting. A significant association was evident between the risk level of LBP and bending posture (p=0.031, OR=1.18–133.89), curved spine angle (p=0.024, OR=1.65–196.31), and patients transfer (p=0.011, OR=5.22–176.83). In conclusion, nurse physical activities and their work facilities can induce LBP. Therefore, it is suggested to provide adjustable facilities and wall-mounted tables in the toilets for urine measurements. Meeting the the minimum nurse: patient ratio, providing SOPs, and educating the nurses to control the risks of LBP are also needed.