Cancer is a chronic disease that threaten human life. Cancer regarded as a stressor that can cause psychological problems. The most commonly psychological problem found on the cancer client are anxiety and depression which will affect on quality of life, impact on treatment performed, prolong hospitalization and have a negative effect on prognosis and the survival of client. This research aimed to determine the therapeutic effect of Progressive Muscle Relaxation (PMR) and Logotherapy against anxiety and depression, relaxation ability and ability to interpret life. This study used quasi-experimental design pretest-posttest control group with a sample of 90 people cancer clients who were divided into two intervention groups and one control group. The results showed that anxiety decreased significantly p=0.00 (p<0.05; α=0.05); depression decreased significantly p=0.002 (p<0.05; α= 0.05); ability relaxation increased significantly p=0.00 (p<0.05; α=0.05); and the ability to make sense of life increased significantly p=0.01 (p<0.05; α=0.05) in the group receiving PMR and Logotherapy. PMR therapy and Logotherapy are recommended as advanced nursing therapy in treating cancer clients who experience anxiety and depression.