Pengaruh Laparoscopic Ovarian Drilling terhadap perubahan aliran darah Stroma Ovarium dan Nisbah LH:FSH pada Sindrom Ovarium Polikistik

Objective: To evaluate the impact of laparoscopic ovarian drilling on ovarian stromal blood flow changes and the decrease of LH:FSH ratio in polycystic ovary syndrome. Setting: Raden Saleh Reproductive Clinic, Yasmin clinic and Makmal laboratory Cipto Mangunkusumo teaching hospital, University of Indonesia, Jakarta, Indonesia.Material and methods: Quasi/pre experimental study, from September 2006 to Februari 2007, patients were women with clomiphene-resistant polycystic ovary syndrome (PCOS) and prepared for laparoscopic ovarian drilling. Patients were checked for the serum level (LH and FSH) and Doppler blood flow changes within the ovarian stroma before and one month after laparoscopic ovarian drilling (LOD). We measured LH:FSH ratio and the Doppler indices (pulsatility index and resistance index) before and after LOD.Results: There were 11 patients who participated in this study, the mean age and body mass index were 28 ± 2.1 and 27.55 ± 6.23. The LH:FSH ratio decreased after LOD (1.31 iu/l; p=0.790), resistance index of ovarian stromal blood flow were increased after LOD (0.04; p=0.0284) and pulsatility index were decreased after LOD (0.74; p=0.062). But statistically not significant.Conclusion: After ovarian drilling (LOD) there were decreased in the LH:FSH ratio and pulsatility index, but there were increased in resistance index.