Infant mortality is defined as death that occurring in the first year of life. Infant mortality rate in Indonesia and Cambodia itself is still above the Southeast Asian IMR, while in Philippines is similar to the Southeast Asian IMR. Birth interval is one factor that plays an important role in infant mortality. The purpose of this study was to determine the influence of birth interval on infant mortality in Indonesia, Philippines and Cambodia. This study used data from Demographic Health Survey (DHS). The study design is cross-sectional and sample in each country is 10.162, 4.741 and 4.330 infants. The results show that birth interval <18 months had the greatest risk of infant mortality in Indonesia (OR = 2.43: 95% CI 1.26 - 4.70), Cambodia (OR = 4.39: 95% CI 1,76 - 10,94) compared to 18 - 23 months, 24 - 35 months and > 36 months. While in Philippines 18 - 23 month birth interval is the greatest risk of infant mortality compared to birth interval <18 months and > 24 months (OR = 2.59: 95% CI 1.13 - 5.95). The ideal birth interval to reduce the risk of infant mortality is > 24 months.