Number of diabetes mellitus cases have been increasing every year. Diabetes mellitus patient needs to get information about diabetes mellitus at least after the diagnose were given. Nurse as an educator could give education for diabetes mellitus patient, so that there will be an upgrade of knowledge diabetes mellitus patient. Verbal education need an additional tool such as a modul, in purpose patient can re-evaluate the material that they already get. The purpose of this research is to test the impact of education using self instructional module to level of knowledge about diabetes mellitus to diabetes mellitus patient type 2. This research using quasi experimental with one group pretest postest design with 29 person samples in total with diabetes mellitus type 2 diagnosis. Data collection using questionaire. Statistic analysis using wilcoxon. Research result shows that there are differences of knowledge before and after education by self instructional module (p= 0,000; α=0,05) before and after education by self instructional module. Hopefully this research can be use as health education media in an attempt to upgrade the knowledge of diabetes mellitus patient type 2.