Aphasia is one of the stroke impacts. Currently, the focus of the aphasia intervention in the hospital is physical aspects. The aim of this study was to evaluate the influence of Augmentative and Alternative Communication (AAC) to patients’ communication ability and depression rates in Aphasia Motoric cases. The research design was quasi experiment with the post-test non-equivalent control group approach. The samples were 21 respondents who divided into two groups: 11 respondents in the control group and 10 respondents in the intervention group. Samples were chosen using the consecutive sampling method. This study used the Derby Functional Communication Scale and the Aphasic Depression Rating Scale to evaluate the communication ability and the depression rate of patients. AAC is an alternative way to communicate with patients who have disability verbal. This process used some media such as, a communication book, magazines, newspapers, family photos, cards, stationaries, and music. The AAC method has several activities such as pointing to particular pictures, naming, reviewing, writing, and reading. The study found that there were no significant differences of the communication ability between two groups of samples (p=0.542). In addition, there were significant rates of the depression between two groups of samples (p=0.022). This study suggests that nurses should apply the AAC method in the communication process especially to patients with stoke to facilitate the communication process and to reduce the patient’s depression.