Pendeteksian Ekspresi Biomarker ERK Secara Semi Kuantitatif dan Kuantitatif Pada Kanker Serviks Sebelum Respon Kemoradioterapi

Teja Kisnanto; Rina Tri Wardani; Budiningsih Siregar; Mellova Amir; Setiawan Soetopo; Irwan Ramli; Tjahya Kurjana; Bethy S. Hernowo; Maringan DL Tobing; Devita Tetriana

Pendeteksian Ekspresi Biomarker ERK Secara Semi Kuantitatif dan Kuantitatif Pada Kanker Serviks Sebelum Respon Kemoradioterapi

Teja Kisnanto, Rina Tri Wardani, Budiningsih Siregar, Mellova Amir, Setiawan Soetopo, Irwan Ramli, Tjahya Kurjana, Andrijono, Bethy S. Hernowo, Maringan DL Tobing, Devita Tetriana

Research output: Contribution to journal › Article › peer-review

Abstract

Cervical cancer is a cancer that common in women caused by HPV (Human Papilova Virus). The purpose of this study is to determine the relationship MNK protein expression (Mitogen-Activated Protein Kinase) in patients with cervical cancer before chemoradiotherapy treatment. Sample used was the preparation of microscopic cancer tissue biopsies from patients with advanced cervical cancer (IIB-IIIB) is 20 samples. The method used is immunohistochemistry using MNK biomarkers in cervical cancer tissue biopsies. MNK positive protein expression marked with dark brown color that is contained in the cell nucleus. Chemoradiotherapy response obtained from RSUPN Dr. Cipto Mangunkusumo and Hasan Sadikin Hospital in Bandung. The results show the value of the IRS (Immuno Reactive Score) MNK protein in response to chemoradiotherapy group either higher than the response to chemoradiotherapy group was bad and did not find any relationship IRS MNK protein with chemoradiotherapy response. While the relationship MNK expression responses show a correlation chemoradiotherapy group differences in chemoradiotherapy response between MNK expression negative and MNK expression positive.

Original language	Indonesian
Journal	Jurnal Keselamatan Radiasi dan Lingkungan
Volume	1
Issue number	1
Publication status	Published - 2016

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@article{dca63c1a05574f69aace3647c1d1dcee,

title = "Pendeteksian Ekspresi Biomarker ERK Secara Semi Kuantitatif dan Kuantitatif Pada Kanker Serviks Sebelum Respon Kemoradioterapi",

abstract = "Cervical cancer is a cancer that common in women caused by HPV (Human Papilova Virus). The purpose of this study is to determine the relationship MNK protein expression (Mitogen-Activated Protein Kinase) in patients with cervical cancer before chemoradiotherapy treatment. Sample used was the preparation of microscopic cancer tissue biopsies from patients with advanced cervical cancer (IIB-IIIB) is 20 samples. The method used is immunohistochemistry using MNK biomarkers in cervical cancer tissue biopsies. MNK positive protein expression marked with dark brown color that is contained in the cell nucleus. Chemoradiotherapy response obtained from RSUPN Dr. Cipto Mangunkusumo and Hasan Sadikin Hospital in Bandung. The results show the value of the IRS (Immuno Reactive Score) MNK protein in response to chemoradiotherapy group either higher than the response to chemoradiotherapy group was bad and did not find any relationship IRS MNK protein with chemoradiotherapy response. While the relationship MNK expression responses show a correlation chemoradiotherapy group differences in chemoradiotherapy response between MNK expression negative and MNK expression positive.",

author = "Teja Kisnanto and Wardani, {Rina Tri} and Budiningsih Siregar and Mellova Amir and Setiawan Soetopo and Irwan Ramli and Tjahya Kurjana and Andrijono and Hernowo, {Bethy S.} and Tobing, {Maringan DL} and Devita Tetriana",

year = "2016",

language = "Indonesian",

volume = "1",

journal = "Jurnal Keselamatan Radiasi dan Lingkungan",

number = "1",

}

TY - JOUR

T1 - Pendeteksian Ekspresi Biomarker ERK Secara Semi Kuantitatif dan Kuantitatif Pada Kanker Serviks Sebelum Respon Kemoradioterapi

AU - Kisnanto, Teja

AU - Wardani, Rina Tri

AU - Siregar, Budiningsih

AU - Amir, Mellova

AU - Soetopo, Setiawan

AU - Ramli, Irwan

AU - Kurjana, Tjahya

AU - Andrijono,

AU - Hernowo, Bethy S.

AU - Tobing, Maringan DL

AU - Tetriana, Devita

PY - 2016

Y1 - 2016

N2 - Cervical cancer is a cancer that common in women caused by HPV (Human Papilova Virus). The purpose of this study is to determine the relationship MNK protein expression (Mitogen-Activated Protein Kinase) in patients with cervical cancer before chemoradiotherapy treatment. Sample used was the preparation of microscopic cancer tissue biopsies from patients with advanced cervical cancer (IIB-IIIB) is 20 samples. The method used is immunohistochemistry using MNK biomarkers in cervical cancer tissue biopsies. MNK positive protein expression marked with dark brown color that is contained in the cell nucleus. Chemoradiotherapy response obtained from RSUPN Dr. Cipto Mangunkusumo and Hasan Sadikin Hospital in Bandung. The results show the value of the IRS (Immuno Reactive Score) MNK protein in response to chemoradiotherapy group either higher than the response to chemoradiotherapy group was bad and did not find any relationship IRS MNK protein with chemoradiotherapy response. While the relationship MNK expression responses show a correlation chemoradiotherapy group differences in chemoradiotherapy response between MNK expression negative and MNK expression positive.

AB - Cervical cancer is a cancer that common in women caused by HPV (Human Papilova Virus). The purpose of this study is to determine the relationship MNK protein expression (Mitogen-Activated Protein Kinase) in patients with cervical cancer before chemoradiotherapy treatment. Sample used was the preparation of microscopic cancer tissue biopsies from patients with advanced cervical cancer (IIB-IIIB) is 20 samples. The method used is immunohistochemistry using MNK biomarkers in cervical cancer tissue biopsies. MNK positive protein expression marked with dark brown color that is contained in the cell nucleus. Chemoradiotherapy response obtained from RSUPN Dr. Cipto Mangunkusumo and Hasan Sadikin Hospital in Bandung. The results show the value of the IRS (Immuno Reactive Score) MNK protein in response to chemoradiotherapy group either higher than the response to chemoradiotherapy group was bad and did not find any relationship IRS MNK protein with chemoradiotherapy response. While the relationship MNK expression responses show a correlation chemoradiotherapy group differences in chemoradiotherapy response between MNK expression negative and MNK expression positive.

UR - http://jurnal.batan.go.id/index.php/JKRL/article/view/3144

M3 - Article

VL - 1

JO - Jurnal Keselamatan Radiasi dan Lingkungan

JF - Jurnal Keselamatan Radiasi dan Lingkungan

IS - 1

ER -

Pendeteksian Ekspresi Biomarker ERK Secara Semi Kuantitatif dan Kuantitatif Pada Kanker Serviks Sebelum Respon Kemoradioterapi

Abstract

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