Background: Mandible fracture is one of the most common fractures in facial region. Management of mandible fractures a comprehensive knowledge about anatomical, biomechanic and occlusion factors. These factors are essential to normalize the mandible function with minimal morbidity, and it very much depends on its bone fragments anatomical position. Plate and screw have been used for decades to facilitate the stability of bone fragments in maxillofacial region, and nowadays is still frequently used technique. Objective: Understanding the principal management of mandibular symphysis fracture using two perpendicular mini-plates. Case: A 24 year-old male presented with multiple facial fractures due to traffic accident (mandibular symphysis complete fracture, sagital palatum fracture and inferior orbital rim fracture). Method: Literature study was conducted through Cochrane, Pubmed, ClinicalKey, and Wiley within last 5 years. An article has been retrieved based on the critical appraisal that was subjected to exclusion and inclusion criteria. Results: Among 25 patients with mandibular fractures, surgical procedures were performed through open reduction and internal fixation with the use of 2 mini-plates. Open reduction internal fixation (ORIF) using 2 perpendicular mini-plates was performed, followed by installation of intermaxillary fixation (IMF), and maxillo-mandibular fixation (MMF), to maintain bones stability that was needed to support ossification process of sagital palatal fracture. Conclusion: Management of mandibular fracture using two perpendicular mini-plates upon mandibular symphysis, by combining MMF and IMF for 4 weeks, was successful to obtain a good occlusion with a minimal complication.