Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung

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Abstract

Chitosan is a natural cationic polymer. That cationic property makes chitosan can
form polyelectrolite complex (PEC) with anionic polymer. In this research, pectin
was used as anionic polymer that interact ionically with chitosan. The aim of this
research is to produce and characterize chitosan-pectin PEC that would be used as
matrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixed
in ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The best
condition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. The
differences between chitosan-pectin PEC characteristic and its origin polymer were
shown by functional group analysis, thermal analysis, swelling capacity and gel
strength. The PEC was then used as matrix in floating tablet.
Original languageIndonesian
JournalPharmaceutical Sciences and Research (PSR)
Publication statusPublished - 2010

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