TY - JOUR
T1 - Patterns of care and outcome analysis of nasopharyngeal carcinoma
T2 - An Indonesian single institution study
AU - Faisal, Hamida Hayati
AU - Kubo, Nobuteru
AU - Nuryadi, Endang
AU - Prihartono, Joedo
AU - Atmakusuma, Tubagus Djumhana
AU - Rachmadi, Lisnawati
AU - Oike, Takahiro
AU - Nakano, Takashi
AU - Gondhowiardjo, Soehartati A.
AU - Adham, Marlinda
N1 - Publisher Copyright:
© 2020, Asian Pacific Organization for Cancer Prevention.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Background: Nasopharyngeal cancer is endemic to Southeast Asia. However, there is limited clinical evidence of nasopharyngeal cancer in Indonesia, which has the largest population in Southeast Asia. Methods: Patterns of care and treatment outcomes in 428 patients with newly-diagnosed and pathologically-confirmed nasopharyngeal cancer were retrospectively analyzed. Results: Concurrent chemo-radiotherapy (CCRT) was the first-line treatment for stages I-IVB diseases. The 2-year overall survival (OS) of all patients were 100.0%, 100.0%, 93.8%, 86.2%, 82.9%, and 62.4% for stages I, II, III, IVA, IVB, and IVC, respectively. The 2-year OS of CCRT-treated patients were 100.0%, 100.0%, 92.6%, 82.4%, and 78.3% for stages I, II, III, IVA, and IVB, respectively. Conclusion: The patterns of care and treatment outcomes were potentially consistent with world standards, needing future validation. This is the largest study of newly diagnosed nasopharyngeal cancer in Indonesia, a huge disease burden, providing an important basis for the clinical management of this disease.
AB - Background: Nasopharyngeal cancer is endemic to Southeast Asia. However, there is limited clinical evidence of nasopharyngeal cancer in Indonesia, which has the largest population in Southeast Asia. Methods: Patterns of care and treatment outcomes in 428 patients with newly-diagnosed and pathologically-confirmed nasopharyngeal cancer were retrospectively analyzed. Results: Concurrent chemo-radiotherapy (CCRT) was the first-line treatment for stages I-IVB diseases. The 2-year overall survival (OS) of all patients were 100.0%, 100.0%, 93.8%, 86.2%, 82.9%, and 62.4% for stages I, II, III, IVA, IVB, and IVC, respectively. The 2-year OS of CCRT-treated patients were 100.0%, 100.0%, 92.6%, 82.4%, and 78.3% for stages I, II, III, IVA, and IVB, respectively. Conclusion: The patterns of care and treatment outcomes were potentially consistent with world standards, needing future validation. This is the largest study of newly diagnosed nasopharyngeal cancer in Indonesia, a huge disease burden, providing an important basis for the clinical management of this disease.
KW - Indonesia
KW - Nasopharyngeal carcinoma
KW - Patterns of care
KW - Radiation therapy
KW - Treatment outcome
UR - http://www.scopus.com/inward/record.url?scp=85085539817&partnerID=8YFLogxK
U2 - 10.31557/APJCP.2020.21.5.1481
DO - 10.31557/APJCP.2020.21.5.1481
M3 - Article
C2 - 32458659
AN - SCOPUS:85085539817
SN - 1513-7368
VL - 21
SP - 1481
EP - 1485
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 5
ER -
