Pathophysiology of Emphysema

Research output: Contribution to journalArticle

Abstract

Pulmonary emphysema is part of pathological condition in chronic obstructive pulmonary disease (COPD) which is characterized by lung parenchymal destruction. Morphology classification of emphysema had been made according to histologic structure in pathology. There were some causes known to be the culprit of emphysema; one that caught most attention is protease-antiprotease activity from cigarette smoke exposure. Destructive effect of emphysema gives disturbance of lung function in expiration (obstruction). The primary mechanism is elastic recoil reduction which causes air trapping, lung volume increase, lung compliance increase and airways that is susceptible to collapse. Hyperinflation in emphysema causes some disadvantages which complicate inspiration and give a dyspnea sensation. Equal pressure point drop in emphysema happens because of elastic recoil reduction. This drop may cause early airway closure. (J Respir Indo 2019; 39(1))
Original languageEnglish
JournalJurnal Respirologi Indonesia
Volume39
Issue number1
Publication statusPublished - 2019

Fingerprint Dive into the research topics of 'Pathophysiology of Emphysema'. Together they form a unique fingerprint.

  • Cite this