Parasitic helminth genomics

M. Blaxter, M. Aslett, D. Guiliano, J. Daub, Steven A. Williams, Kunthala Jayaraman, Reda Ramzy, Alan Scott, Taniawati Supali, Barton Slatko

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

The initiation of genome projects on helminths of medical importance promises to yield new drug targets and vaccine candidates in unprecedented numbers. In order to exploit this emerging data it is essential that the user community is aware of the scope and quality of data available, and that the genome projects provide analyses of the raw data to highlight potential genes of interest. Core bioinformatics support for the parasite genome projects has promoted these approaches. In the Brugia genome project, a combination of expressed sequence tag sequencing from multiple cDNA libraries representing the complete filarial nematode lifecycle, and comparative analysis of the sequence dataset, particularly using the complete genome sequence of the model nematode C. elegans, has proved very effective in gene discovery.

Original languageEnglish
JournalParasitology
Volume118
Issue numberSUPPL.
Publication statusPublished - 23 Aug 1999

Keywords

  • Bioinformatics
  • Brugia malayi
  • Caenorhabditis elegans
  • Expressed sequence tag
  • Genome mapping
  • Genomics
  • Parasitic genomes
  • Schistosoma

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