Therapeutic responses of 44 patients with well differentiated thyroid carcinoma who had received I-131 therapy were evaluated. Thirty patients had papillary carcinoma and fourteen with follicular carcinoma. Of these, 11% patients had metastases to regional nodes and 11% had distant metastases. I- 131 therapy with the dose of 80 mCi was given to 24 patients with papillary carcinoma and 10 patients with follicular carcinoma who had no distant metastases. Patients with distant metastases consisting of 6 patients with papillary carcinoma and 4 patients with follicular carcinoma were treated with 100 mCi I-131. Of the patients with papillary carcinoma successful ablation was obtained in 58% patients with a 80 mCi initial dose and increased to 79% patients after the second dose. Metastatic control was obtained in 33% patients with 100 mCi and increased to 67% patients after the second dose. Of the patients with follicular carcinoma, successful ablation was obtained in 70% patients and increased to 80% patients after the second dose. Metastatic control was obtained in 50% patients after the second dose. It is assumed that efficacy of ablation with 80 mCi as initial dose is higher in patients with follicular carcinoma than the papillary type, while the metastatic lesions in both histologic types should be treated with more additional doses of 100 mCi.
- Follicular type
- Papillary type
- Thyroid carcinoma
- Treatment of thyroid carcinoma